Trace Elements in Medicine (Moscow)
2021, 22(1): 52-59
ORIGINAL PAPERS

INFLUENCE OF ALIMENTARY INSUFFICIENCY OF CALCIUM, MAGNESIUM AND IODINE ON RAT VITAMIN STATUS

O.A. Vrzhesinskaya, V.M. Kodentsova, N.A. Beketova, O.V. Kosheleva, L.V. Shevyakova, S.N. Leonenko, A.A. Sokolnikov, I.V. Aksenov

Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240 Moscow, Ustyinskiy proezd, d. 2/14

DOI: 10.19112/2413-6174-2021-22-1-52-59 

ABSTRACT. The diet of the majority of the population of Russia is characterized by an insufficient content of a number of micronutrients, including macro- and micronutrients. The aim of the study is to characterize in a rat model experiment the effect of combined nutritional deficiency of calcium, magnesium and iodine on the availability of other mineral substances, vitamin metabolism and biochemical parameters blood plasma. The lack of minerals in growing Wistar male rats with an initial body weight (51.4 ± 0.5) g was created for 23 days by halving of a calcium, magnesium and iodine in the salt mixture. Alimentary deficiency of calcium, magnesium and iodine in growing rats significantly and multidirectionally affected the metabolism of other minerals and vitamins, as well as a number of diagnostically significant indicators of blood and urine. In rats of the experimental group, the liver concentration of α-tocopherol, vitamin B1 and retinol palmitate decreased, the concentration of iron and zinc increased, the copper content in the whole brain decreased significantly. The molar ratio of γ- and α-tocopherols in blood plasma was increased, the concentration of the circulating form of vitamin D decreased. The ratio of AlAT / AsAT (de Ritis coefficient) markedly decreased due to increased activity of AlAT. Phosphate reabsorption decreased slightly. Increased urinary excretion of riboflavin was accompanied by a decrease in its concentration in blood plasma. The conclusion that insufficient intake of calcium, magnesium and iodine may disturb vitamin-mineral status of organism has been made.

KEYWORDS: multiple mineral deficiency, calcium, magnesium, iodine, vitamins, rats.