Trace Elements in Medicine (Moscow)
2020, 21(2): 34-40
ORIGINAL PAPERS0

INFLUENCE OF ZINC ALIMENTARY TREATMENT ON NORMAL AND PATHOLOGICAL MOTOR BEHAVIOR OF RATS

A.F. Yakimovskii

Pavlov University, L`va Tolstogo str. 6-8, St.-Petersburg, Russian Federation;
Pavlov Institute of Physiology Russian Academy of Science, St.-Petersburg, Russia

DOI: 10.19112/2413-6174-2020-21-2-34-40 

ABSTRACT. Chronic experiments were performed on rats to study the influence of prolonged acetic zinc alimentary treatment on normal (spontaneous movement in “open field and condition active avoidance reflex in “shuttle box”) and abnormal (choreomyoclonic hyperkinesia, produced by intrastriatal microinjections GABA-A receptors antagonist picrotoxin  2 mcg) motor behavior. 4 mg acetic zinc is used by rats with food ball once a day. 12 mg zinc сonsumption by rats per week did not affected on normal behavior. While 24 mg is produced smaller negative effects on rats reflex performance to 6570% correct responses (of total present during the experiment) but to improved condition avoidance behavior, violated by picrotoxinin rats and reduce the reproducibility of picrotoxin-induced choreo-mioclonic hyperkinesis (human Huntington disease hyperkinesis analog). The influence of zinc on motor behavior depending on its dose and mode of administration is discussed.

KEYWORDS: zinc, picrotoxin, neosrtiatum, free locomotor activity, avoidance behavior, hyperkinesis.