Trace Elements in Medicine (Moscow)
2020, 21(2): 23-33
ORIGINAL PAPERS0

TRACE ELEMENTS IN THE BLOOD COAGULATION SYSTEM IN ISCHEMIC STROKE: A CLINICAL STUDY

L.L. Klimenko¹, A.I. Deev¹, I.S. Baskakov¹, M.N. Budanova¹, A.H. Zabirova², M.S. Uzhenceva³, A.N. Mazilina⁴, M.S. Savostina⁴, O.V. Senko⁵, A.V. Kuznecova⁶

¹ Institution of the Russian Academy of Sciences Institute of Chemical Physics named after N.N. Semenova RAS, Moscow, Russia
² Moscow State University named after M.V. Lomonosov Moscow, Russia
³ Novosibirsk State Medical University, Novosibirsk, Russia
⁴ KН № 123 FMBA of Russia, Odintsovo, Moscow region, Russia
⁵ Computing Center RAS, Moscow, Russia
⁶ Institute of Biochemical Physics. N.M. Emanuel RAS, Moscow, Russia

DOI: 10.19112/2413-6174-2020-21-2-23-33 

ABSTRACT. The basis of the mechanism of ischemic brain tissue are hematological disorders. It is known that divalent ions influence the formation and structure of fibrin. In connection with this fact, a change in macro- and microelement balance serves as a marker of neurotrophic disturbances in the brain long before their clinical manifestations. The imbalance of metal-ligand homeostasis is an unfavorable background for the debut of ischemic stroke. In a multifactorial coagulation system, specific proteins - Protein C and D-dimers - occupy a key place. Many macro- and microelements are mediators of homeostasis and thrombosis: violations of elemental homeostasis are the molecular basis of the ischemic process. In a study conducted in a clinical setting, the combined dynamics of protein C and D-dimers and a complex of macro- and microelements are shown with a high degree of certainty. Using Spearman correlation analysis, reliable correlations were revealed between the concentrations of protein C, D-dimers and macro- and microelements in patients diagnosed with ischemic insult. In the final part of the mathematical processing of the results, multiple regression analysis was used, with the help of which a reliable relationship between protein C, a component of the blood coagulation system, and the concentration of a complex of macro- and microelements contributing to the central mechanism of etiopathogenesis of ischemic stroke is shown: R = 0.95938848, R₂ = 0.92042626.

KEYWORDS: protein C, D-dimers, macro- and microelements.