Trace Elements in Medicine (Moscow)
2019, 20(2): 18-27
ORIGINAL PAPERS

NEUROSPECIFIC ELEMENTS IN CHILDREN 6-7 YEARS, MOVED IN CRITICAL CONDITIONS AT BIRTH

K.E. Popova¹, O.A. Senkevich¹, A. Skretnev², O.V. Lemeschenko¹, N.V. Berdnikov³ , A.V. Shtareva³ , A.Yu. Lushnikova³

¹ Far Eastern State Medical University, 680000, ul. Muravyev-Amursky, 35, Khabarovsk, Russia
² KGBUZ «Children's Regional Clinical Hospital» named after A.K. Piotrovich, Khabarovsk, Russia
³ DVO RAN «Institute of Tectonics and Geophysics. Yu.A. Kosygina», Khabarovsk, Russia

DOI: 10.19112/2413-6174-2019-20-2-18-27 

ABSTRACT. Critical conditions at birth with the implementation of hypoxic-ischemic damage to the central nervous system account for up to 50% of perinatal brain damage, exerting a destabilizing effect on higher autonomic centers, leading to various autonomic dysfunctions (Serikova et al., 2013), further disadaptation and disability of children. Having a wave-like flow, they often manifest during critical periods of postnatal development, which are characterized by intensity of morphofunctional rearrangements occurring in the body (Khaletskaya et al., 2009; Serikova et al., 2013). The clinical picture of posthypoxic changes in the nervous system is polymorphic, status changes are ambiguous, and laboratory diagnostics will provide reliable information on the state of elemental and hormonal homeostasis, which can be the basis of preventive measures to prevent controlled pathology. The aim of the study was to determine the level of neurospecific elements in children 67 years old, who endured critical conditions at birth. Results of the study: when assessing the elemental composition in serum, there was a significant calcium deficiency in both subgroups (61% in the first and 67% of the second) and zinc (75% and 83% of the cases, respectively); exceeding the reference values of magnesium (50% and 47%) and copper (58% and 47%), then determines the imbalance of the microelement status. The cadmium content in the second subgroup (0.67 ± 0.09) was significantly higher than in the first, not exceeding the reference values (p < 0.05). The level of mercury reliably prevailed in the first subgroup (7.30 ± 0.54), going beyond the reference values in only one case.

KEYWORDS: neurospecific elements, critical conditions, hypoxia, elemental imbalance, zinc, calcium, magne-sium, copper, toxic elements.