Trace Elements in Medicine (Moscow)
2019, 20(1): 21-26
ORIGINAL PAPERS

TEMPORAL STRUCTURE OF ELECTROLYTES AND TRACE ELEMENTS HOMEOSTASIS IN STRESS AND ISCHEMIC HEART DISEASE. CLINICAL AND EXPERIMENTAL INVESTIGATION

L.G. Asatryan¹, S.M. Chibisov², L.A. Babayan¹, I.A. Mirzoyan¹, A.K. Gulyan³, P.K. Sarafyan³, G.S. Gaboyan¹, M.A. Zohrabyan¹

¹ Armenian Medical Institute, Titogradyan 14, Yerevan, Republic of Armenia
² Peoples' Friendship University of Russia, Chair of Pathophysiology of V.A. Frolov, Miklukho-Maklaya str. 6, Moscow, 117198, Russia
³ «Erebuni» Medical Center, Urgent Cardiology Department, Titogradyan 14, Yerevan, Republic of Armenia

DOI: 10.19112/2413-6174-2019-20-1-21-26 

ABSTRACT. Four-hour urine and blood specimen were collected over a span of 48-120 hours from 70 healthy subjects, 40 patients with IHD, 15 intact rabbits, 20 rabbits under the action of stress. Each specimen was analyzed for electrolytes (sodium, potassium, phosphorus, chlorine, calcium, magnesium) and trace elements (iron, copper, zinc, chromium, cadmium, vanadium). Rhythm parameters have been estimated by dispersion analysis for nonsinusoidal rhythms and by nonlinear least squares method for sinusoidal rhythms. In healthy subjects in 91% cases of 593 rhythmological investigations urinary excretion electrolytes and trace elements statistically significant rhythms were observed. In healthy subjects and in intact rabbits electrolytes and trace elements rythms were circadian in 7592% of cases. Acrophases of rhythms were mostly individual. In early stage of IHD and in rabbits under the action of stress electrolytes and trace elements rhythms were statistically non significant in 20-43% of cases. Among significant rhythms of infradian ones (45-60%) prevail. Mesors of sodium, chlorine, phosphorus, iron, copper, zinc, chromium and vanadium excretion rhythms were statically significantly higher than in healthy subjects. Mesors of calcium and magnesium were statically significantly lower than in healthy subjects. Amplitudes of chlorine, phosphorus, iron, copper, zinc were statistically significantly higher than in healthy subjects. Amplitudes of sodium/potassium, magnesium statistically signifi-cantly lower than in healthy subjects.

KEYWORDS: ultradian, circadian, infradian rhythms, mesor, amplitude, acrophase.