Trace Elements in Medicine (Moscow)
2017, 18(1): 35–37
ORIGINAL PAPER

THE INTERACTION OF ENTEROBACTERIA WITH METAL COMPOUNDS, FOR EXAMPLE NANOPARTICLES OF ALUMINUM OXIDE

M.V. Fomina, E.A. Mikhailova, S.B. Kirgizova, L.M. Aznabaeva, O.O. Zherebyatyeva

Orenburg State Medical University, Sovetskaya St., 6, Orenburg, 460000, Russia

DOI: 10.19112/2413-6174-2017-18-1-35-37 

ABSTRACT. The discovery of the fact of microbial biofilm formation is one of the most important achievements of medical and clinical microbiology in recent years. According to some reports, in more than 80% cases of infectious diseases the pathogen forms a biofilm that provide it substantial advantages compared with isolated cells, contribute to emergence of populations of so-called «persisters». A significant amount of work has been devoted to studying the problem of the influence of various factors on the biofilm formation by pathogenic and opportunistic microorganisms. Along with this, the biological properties of nanoparticles, whose sizes are 10-30 times smaller than Escherichia coli, are actively discussed in the literature. Special attention of researchers is attracted by aluminum oxide, the use of which is associated with cosmetic and medical fields. The prolonged action of biologically active particles of metals is associated with the presence on their surface of a protective oxide film, preventing rapid dissolution of the base metal. How-ever, the influence of nanoscale particles on the processes of microbial biofilms formation is not well known and can be of great interest for both theoretical and practical medicine. This work studied the influence of nanoparticles of aluminum oxide on the bioincubation of E. coli isolated from patients with chronic pyelonephritis. It was shown that nanosized aluminum oxide (30 and 70 nm particles) reduced microbial content of E. coli clones regardless of the particles concentration. It was found that influence of aluminium oxide nanoparticles, first the 30 nm ones, suppressed the ability of E. coli strains to form microbial biofilms. The obtained results showed the promise of further investigations of the influence of metal nanostructures on microbiological objects.

KEYWORDS: nanoparticles, aluminum oxide, microbial biofilm.