Trace Elements in Medicine (Moscow)
2017, 18(1): 22–26
ORIGINAL PAPER

ANALYSIS OF ELEMENTAL HOMEOSTASIS OF BLOOD PLASMA IN DIFFERENT PHASES OF PULMONARY TUBERCULOSIS

L.M. Obukhova1, E.I. Erlykina1, A.V. Aliyev2, R.E. Chobanov2, V.G. Pimenov3, I.I. Evdokimov3

1 Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia
2 Azerbaijan Medical University, Baku, Azerbaijan
3 G.G. Devyatykh Institute of Chemistry of High-Purity Substances of the Russian Academy of Sciences, Nizhny Novgorod, Russia

DOI: 10.19112/2413-6174-2017-18-1-22-26 

ABSTRACT. A content of macro- and trace elements in blood plasma of 35 healthy people from a northern region of Azerbaijan and from the Nizhni Novgorod region of Russian Federation, as well as blood plasma of 23 patients with pulmonary tuberculosis in various phases was examined by inductively coupled plasma atomic emission spectrometry. Blood plasma elemental homeostasis was not significantly different depending on residence, with the exception of potassium level (1.3 times more in Russians) and strontium level (10 times more in citizens of Azerbaijan). There was no valid difference in blood plasma elements content found in patients with focal pulmonary tuberculosis. In pulmonary tuberculosis, followed by apolexis, the content of calcium, copper, zinc and iron were significantly increased in a comparison with healthy persons. Analysis of such macro- and trace elements content can possibly be applied in detecting transition of an early stage of pulmonary tuberculosis into infiltrative and/or cavernous tuberculosis, when a patient be-comes epidemiologically dangerous for the wider public.

KEYWORDS: pulmonary tuberculosis, focal stage, cavernous stage, macroelements, trace elements, calcium, copper, zinc, iron.