ABSTRACT.
The number of patients suffering from both asthma and obesity is increasing, which affects the course of the disease. Both processes are chronic, complex, and multifactorial in nature, and the imbalance of micro-nutrients in the body plays a role in their etiology.
The aim of this study is to investigate the serum levels of micronutrients in children with asthma comorbid with obesity.
Materials and methods. 46 children with a diagnosis of BA were examined, including 26 patients with BA and obesity (the main group) and 20 patients with BA and normal BMI (the comparison group). The control group consist-ed of 26 healthy children of the same gender and age. Biochemical study of protein, carbohydrate and lipid spectrum of serum was carried out on a biochemical automatic analyzer SAPPHIRE 400 (Japan). The study of ME content in blood serum was carried out by atomic absorption analysis on a spectrophotometer Hitachi Z300 (Japan).
Results. The microelement profile in children with BA and obesity was characterized by a decrease in the concentration of lithium, manganese, copper, iron in the blood serum (p<0.05) and an increase in the content of nickel, cobalt, cop-per.
Conclusion. The obtained data indicate a close relationship between metabolic disorders and inflammatory pro-cesses in the pathology under study. However, these issues require further study in the search for significant predictors of the influence of micronutrients on carbohydrate and lipid metabolism in children with bronchial asthma and obesity, depending on diet, environmental, and other factors, including genetic ones, in order to develop personalized prevention and treatment programs.
KEYWORDS: micronutrients, children, bronchial asthma, obesity
For citation: Evseeva G.P., Suprun S.V., Telepneva R.S., Suprun E.N., Poltavchenko A.E., Knizhnikova E.V., Kozlov V.K., Lebedko O.A. Assessment of the content of microelements in the serum of patients with bronchial asthma and obesity. Trace elemets in medicine. 2025;26(4):4754. DOI: 10.19112/2413-6174-2025-26-4-47-54
REFERENCES
Al-Fartusie F.S., Abood M.J., Al-Bairmani H.K., Mohammed A.S. Evaluation of some trace elements in sera of asthma patients: a case control study. Folia Med. (Plovdiv). 2021; 63(5):797-804. DOI: 10.3897/folmed.63.e60506.
Azab S.F., Saleh S.H., Elsaeed W.F., Elshafie M.A., Sherief L.M., Esh A.M.H. Serum trace elements in obese Egyptian children: a case–control study. Ital. J. Pediatr. 2014; 40: 20. DOI: 10.1186/1824-7288-40-20.
Bartziokas K., Papaioannou A.I., Drakopanagiotakis F., Gouveri E., Papanas N., Steiropoulos P. Unraveling the Link between Ιnsulin Resistance and Bronchial Asthma. Biomedicines. 2024 Feb 16;12(2):437. DOI: 10.3390/biomedicines12020437.
Baruwa P., Sarmah K.R. Obesity and asthma. Lung India. 2013; 30(1): 38–46. DOI: 10.4103/0970-2113.106132.
Bolotova N.V., Skalny A.A., Filina N.Yu., Cherednikova K.A., Kurdiyan M.S., Logacheva O.A., Bochkarev I.A., Cuhushina E.E. Manifestation of microelementoses in children with different nutritional status. Trace elements in medicine. 2022; 23(4): 62−69. DOI: 10.19112/2413-6174-2022-23-4-62-69 (In Russian).
Chen Z., Salam M.T., Alderete T.L., Habre R., Bastain T.M., Berhane K, Gilliland F.D. Effects of childhood asthma on the de-velopment of obesity among school-aged children. Am. J. Respir. Crit. Care Med. 2017; 195:1181–8. DOI: 10.1164/rccm.201608-1691OC 31.
Chichkova N.V., Gasparyan A.A., Gitel E.P., Serova N.S., Fomin V.V. Asthma in Overweight and Obese Patients: Assessment of Adipokine Profile with Different Fractions of Adipose Tissue. Practical pulmonology. 2019; 3: 4–9. (In Russian).
Chuchalin A.G., Avdeev S.N., Aisanov Z.R., Belevskiy A.S., Vasil’eva O.S., Geppe N.A., Ignatova G.L., Knyazheskaya N.P., Malakhov A.B., Meshcheryakova N.N., Nenasheva N.M., Fassakhov R.S., Khaitov R.M., Il’ina N.I., Kurbacheva O.M., Astafieva N.G., Demko I.V., Fomina D.S., Namazova-Baranova L.S., Baranov A.A., Vishneva E.A., Novik G.A. Federal guidelines on diagno-sis and treatment of bronchial asthma. Pul’monologiya. 2022; 32 (3): 393–447. DOI: 10.18093/0869-0189-2022-32-3-393-447. (In Russian).
De A., Rastogi D. Association of pediatric obesity and asthma, pulmonary physiology, metabolic dysregulation, and atopy; and the role of weight management. Expert Rev. Endocrinol. Metab. 2019; 14: 335–49. DOI: 10.1080/17446651.2019.1635007.
Dubey P., Thakur V., Chattopadhyay M. Role of Minerals and Trace Elements in Diabetes and Insulin Resistance. Nutrients. 2020;12(6): 1864. DOI: 10.3390/nu12061864.
Evseeva G.P., Suprun S.V., Kozlov V.K., Suprun E.N., Lebed’ko O.A. Influence of imbalance of trace elements on the function of the immune system. Trace Elements and Electrolytes. 2021; 38(3): 138. DOI 10.5414/TEX01685.
Feng W., Cui X., Liu B., Liu C., Xiao Y., Lu W., Guo H., He M., Zhang X., Yuan J., Chen W., Wu T. Association of urinary metal profiles with altered glucose levels and diabetes risk: a population-based study in China. PLoS One. 2015; 10(4): e0123742. DOI: 10.1371/journal.pone.0123742.
Galchenko A.V., Sherstneva A.A. Conditionally essential ultra trace elements in nutrition of vegetarians and vegans. nickel, lithi-um, vanadium, germanium. Trace elements in medicine. 2015; 16(2): 42−46. DOI: 10.19112/2413-6174-2021-22-2-3-16. (In Russian).
Global Initiative for Asthma. Global Strategy for Asthma Manangement and Prevention, 2021. Available online at: www.ginasthma.org.
González-Domínguez Á., Jurado-Sumariva L., González-Domínguez R. Association between childhood obesity, trace elements, and heavy metals: Recent discoveries and future perspectives. Obes Rev. 2024; 25(8): e13764. DOI: 10.1111/obr.13764.
Grabeklis A.R., Skalny A.V., Ajsuvakova O.P., Skalnaya A.A., Mazaletskaya A.L., Klochkova S.V., Chang S.J.S., Nikitjuk D.B., Skalnaya M.G., Tinkov A.A. A Search for Similar Patterns in Hair Trace Element and Mineral Content in Children with Down's Syndrome, Obesity, and Growth Delay. Biol. Trace Elem. Res. 2020; 196(2): 607–617. DOI: 10.1007/s12011-019-01938-6.
Kim M.H., Choi M.K. Seven Dietary Minerals (Ca, P, Mg, Fe, Zn, Cu, and Mn) and Their Relationship with Blood Pressure and Blood Lipids in Healthy Adults with Self-Selected Diet. Biol Trace Elem. 2013; 153: 69–75. DOI: 10.1007/s12011-013-9656-1.
Kudrin A.V., Gromova O.A. Microelements in Immunology and Oncology. Moscow: GEOTAR-Media, 2007. 544 p. (In Rus-sian).
Lapik I.A., Gapparova K.M. Macro- and microelements in the pathogenesis and therapy of bronchial asthma: molecular mecha-nisms and evidence base. Trace elemets in medicine. 2025; 26(3): 3−10. DOI: 10.19112/2413-6174-2025-26-3-3-10. (In Russian).
Luo L., Chen G., Zhou Y., Xiang Y., Peng J. Dietary intake, antioxidants, minerals and vitamins in relation to childhood asthma: a Mendelian randomization study. Front. Nutr. 2024; 11: 1401881. DOI: 10.3389/fnut.2024.1401881.
Luo X., Liu Z., Ge X., Huang S., Zhou Y., Li D., Li L., Chen X., Huang L., Hou Q., Cheng H., Xiao L., Liu C., Zou Y., Yang X. High manganese exposure decreased the risk of high triglycerides in workers: a cross-sectional study. BMC Public Health. 2020; 20(1): 874. DOI: 10.1186/s12889-020-09011-x.
Luo Y., Luo D., Li M., Tang B. Insulin Resistance in Pediatric Obesity: From Mechanisms to Treatment Strategies. Pediatr Dia-betes. 2024 Jun 28; 2024: 2298306. DOI: 10.1155/2024/2298306.
Mao S., Wu L., Shi W. Association between trace elements levels and asthma susceptibility. Respir. Med. 2018; 145:110–119. DOI: 10.1016/j.rmed.2018.10.028.
Mohan A., Grace J., Wang B.R., Lugogo N. The effects of obesity in asthma. Curr. Allergy Asthma Rep. 2019; 19:49. DOI: 10.1007/s11882-019-0877-z.
Pootheri A., Lopez W.M., Saraswathy R. A case-control study on asthma and obese patients: Influence of lifestyle patterns, se-rum trace elements, heavy metals, and total antioxidants. Heliyon. 2024; 10: e29270. DOI: 10.1016/j.heliyon.2024.e29270.
Skalny A.V. Rudakov I.A. Bioelements in Medicine. Moscow: ONIKS 21 Century Publishing House: Mir. 2004. 272 p. (In Rus-sian).
Suprun E.N., Suprun S.V., Evseeva G.P., Lebedko O.A. Exogenous factors influencing the course of bronchial asthma. Yakut Medical Journal, 2025; 91(3): 108–111. DOI: 10.25789/YMJ.2025.91.27. (In Russian).
Tay T.R., Radhakrishna N., Hore-Lacy F., Smith C., Hoy R., Dabscheck E., Hew M. Comorbidities in difficult 93 asthma are in-dependent risk factors for frequent exacerbations, poor control and diminished quality of life. Respirology. 2016; 21(8): 1384–1390. DOI: 10.1111/resp.12838.
Tinkov A.A., Sinitskii A.I., Popova E.V., Nemereshina O.N., Gatiatulina E.R., Skalnaya M.G., Skalny A.V., Nikonorov A.A. Alteration of local adipose tissue trace element homeostasis as a possible mechanism of obesity-related insulin resistance. Med Hypoth-eses. 2015; 85(3): 343–7. DOI: 10.1016/j.mehy.2015.06.005.
Information about the authors:
Galina P. Evseeva – Dr.Sc. (Med.), Deputy Director on Scientific Work,
Chief Research Scientist of the Group of Health and Environmental Problems of Mother and Child Health, Laboratory of Integral Methods of Bronchopulmonary and Perinatal Pathology Research
E-mail: evceewa@yandex.ru; https://orcid.org/0000-0002-7528-7232
Stefania V. Suprun – Dr.Sc. (Med.), Chief Research Scientist of the Group of Health and Environmental Problems
of Mother and Child Health, Laboratory of Integral Methods of Bronchopulmonary and Perinatal Pathology Research
E-mail: stefanya-suprun@yandex.ru; https://orcid.org/0000-0001-6724-3654
Regina S. Telepneva – Research Scientist of the Group of Health and Environmental Problems of Mother and Child Health, La-boratory of Integral Methods of Bronchopulmonary and Perinatal Pathology Research
Е-mail: pupykin84@mail.ru; https://orcid.org/0000-0003-2873-2353
Evgeniy N. Suprun – Dr.Sc. (Med.), Senior Research Scientist of the Group of Health and Environmental Problems
of Mother and Child Health, Laboratory of Integral Methods of Bronchopulmonary and Perinatal Pathology Research; As-sociate Professor, Department of Hospital and Faculty Pediatrics with a Course of Propaedeutics of Children’s Diseases
E-mail: evg-suprun@yandex.ru; https://orcid.org/0000-0002-1089-8844
Alesya E. Poltavchenko – Post-graduate Student
E-mail: panova.alesya@mail.ru; https://orcid.org/0009-0002-5062-8659
Elena V. Knizhnikova – Post-graduate Student
E-mail: 1904lenok@mail.ru; https://orcid.org/0000-0003-0377-4805
Vladimir K. Kozlov – Dr.Sc. (Med.), Professor, Corresponding Member of RAS, Chief Research Scientist
E-mail: iomid@yandex.ru; https://orcid.org/0000-0001-9978-1043
Olga A. Lebed’ko – Dr.Sc. (Med.), Director of the Khabarovsk Branch of Far-Eastern Scientific Center of Physiology and Pa-thology of Respiration – Research Institute of Maternity and Childhood Protection
E-mail: leoaf@mail.ru; https://orcid.org/0000-0002-8855-7422
Conflict of interest
The authors declare no obvious and potential conflicts of interest related to the publication of this article.
Поступила 24 октября 2025 года
Принята к публикации 30 ноября 2025 года