ABSTRACT. Arsenic waters are rare large waters that are used for internal and external use. Currently, the issue of studying arsenic waters, the possibilities of their use in spa treatment, as well as balneological assessment are relevant.
The aim of the study is to study modern problems of external and internal use of mineral arsenic waters in spa treatment for the purpose of further research to determine.
Materials and method. A search of literary sources on the impact of natural arsenic mineral waters on the human body was conducted. A total of about 250 sources were analyzed, the final analysis included 38 sources of literature.
Results. Arsenic is involved in many important biological processes, regulates the function of the central nervous system, musculoskeletal system, hematopoiesis, and the body's immune system. In a living organism, the connection of arsenic with other elements can both enhance and reduce its biochemical effects, so different compositions of arse-nic waters can cause various pathological and physiological reactions in the body. An important area of research is the study of the carcinogenic properties of arsenic and the study of the "dose-effect" issue in experimental and clinical studies, since indications and contraindications for the use of mineral waters with an arsenic content of less than 0.7 mg / dm3 have not yet been developed.
Conclusions. The effectiveness of arsenic waters is that arsenic is actively absorbed when drinking such waters, but is excreted from the body more slowly than pharmaceuticals, which provides a longer therapeutic effect with smaller doses of arsenic, which in the usual sense is associated with the word "poison". The carcinogenicity of arsenic and its compounds is still being studied by specialists, the main question is: "dose-effect". Promising areas of further re-search are the study of the mechanisms of action of individual groups of arsenic waters for various diseases for use in sanatorium and resort organizations.
KEYWORDS: mineral water, arsenic, minerals.
For citation: Parnyakova L.L., Guryevskaya E.A., Semenova I.V., Gorelikova O.N., Grishechkina I.A., Yakovlev M.Yu., Ryzhova I.N. Effects of natural mineral arsenic waters on the human body. Trace elemets in medicine. 2025;26(2):2013. DOI: 10.19112/2413-6174-2025-26-2-20-30.
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Information about the authors:
Lyudmila L. Parnyakova – Engineer of the Center for Testing and Examination of Natural Healing Resources; Е-mail: ParnyakovaLL@nmicrk.ru; ORCID: 0009-0002-7768-3236; SPIN: 4104-0953
Ekaterina A. Guryevskaya – Research Scientist; ORCID: 0000-0001-8048-5754; SPIN: 9497-1073
Irina V. Semenova – Research Scientist; ORCID: 0000-0001-8227-9962; SPIN: 5073-7882
Olga N. Gorelikova – Research Scientist; ORCID: 0000-0003-2031-6582; SPIN: 5619-6461
Irina A. Grishechkina – Research Scientist; ORCID: 0000-0002-4384-2860; SPIN: 2212-9967
Maxim Yu. Yakovlev – Dr.Sc.(Med.), Chief Research Scientist, Department of Studying the Mechanisms of Action of Physical Factors; ORCID: 0000-0002-5260-8304; SPIN: 3832-3419
Irina N. Ryzhova – MD, Ph.D. (Med.), Leading Specialist of the Hygiene Department; ORCID: 0000-0003-0696-5359; SPIN: 8321-1192
Conflict of interest
The authors declare no obvious and potential conflicts of interest related to the publication of this article.