ABSTRACT. The objective of the present study was investigation of the elemental composition of sperm plasma in the male population of the North to assess its role in the risk of developing such types of pathospermia as oligozoospermia, asthenozoospermia, teratozoospermia and oligoastenoteratozoospermia (OAT syndrome) in idiopathic male infertility.
Materials and methods. The elemental composition of spermoplasm was performed using inductively-coupled plasma mass-spectrometry.
Results. It was established that the content of such essential chemical elements as potassium, magnesium, phosphorus, zinc, copper and selenium was below the limit of physiologically optimal values, both in the group of men with idiopathic infertility and in men who realized their reproductive function. At the same time, the concentrations of P (p = 0.008), Cu (p = 0.047) and Se (p < 0,001) turned out to be significantly lower in the group of patients with idiopathic male infertility than in the group of men with realized reproductive function, but there were no significant differences between the levels of K, Mg and Zn in the seminal plasma of men in the study groups was not detected. The average values of Ca, Fe and Mn content in the study groups were within the reference values, while the Mn level in patients of the main group was at the lower limit of normal, and the Fe level (p = 0.02) was 70% lower than in men control group. Concentrations of toxic elements: mercury, lead and cadmium in both groups did not exceed the upper limit of normal.
Conclusion. The data obtained is evidence of the need for early pharmaconutraceutical correction of elemental status in the male population of the North to prevent infertility, as well as a personalized and comprehensive assessment of the metabolism of chemical elements in men with idiopathic infertility to increase the effectiveness of treatment.
KEYWORDS: elemental status, idiopathic male infertility, pathospermia, spermoplasm, North.
For citation: Belik O.S., Korchin V.I. Comparative assessment of the elemental composition of seminal plasma in the male population of the north and its role in the risk of developing pathospermia in idiopathic male infertility. Trace elemets in medicine. 2024;25(4):31−40. DOI: 10.19112/2413-6174-2024-25-4-31-40.
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