ABSTRACT.
The presented work presents an analysis of the results of a study assessing the biological effect of
chemical compounds of cobalt and copper on representatives of the structural intestinal microbiome using the model
Enterococcus sp., Lactobacillus sp. and E. coli. The data obtained indicate a high level of tolerance of the studied
strains to chemical compounds of essential elements in concentrations from 0.125 M/l to 0.031 M/l. A pronounced prolonging effect of cobalt and copper on dynamic growth rates was established. However, the level of sorption of these elements is insignificant and averages 10.7% for E. coli (Cu) and 8.3% for Lactobacillus sp. (Co). It was experimentally
established that the population size of E. coli has significantly low values against the background of cobalt intoxication
by 25.27% (p<0.05). An increase in the cell population of this microorganism can be associated with a decrease in
competitiveness for nutrients against the background of a decrease in the population of other microorganisms, as evidenced by the results of counting Enterococcus sp.
KEYWORDS: cobalt, copper, acute intoxication, bioaccumulation.