ABSTRACT.
The objective of the present study to determine the structural features of the parotid salivary glands
and the features of mineral metabolism in the mother–fetus-offspring system under the action of industrial vibration.
Materials and methods.
The experiment was conducted on Wistar rats. The animals were divided into 2 groups:
1 control group - 10 females with intact pregnancy; 2 group. -10 animals exposed to vibration of category 3A (general
technological) for 60 minutes from the 9th to the 18th day of pregnancy. On day 20, the animals were removed from the
experiment. Parotid salivary glands were taken for examination under a light and electron microscope. Morphometry
was performed by the method of point counting under a light microscope using a square test system with 88 points. The
content of Ca, Cd, Cu, Fe, Mg, P, Pb, Se, and Zn in the liver of females was determined by inductively coupled plasma
mass spectrometry (ICP-MS).
Results.
Changes in the structure of the parotid salivary gland in the mother-fetus-offspring system indicate a depletion of the microcirculatory bed (MCR) and difficulty in the outflow of saliva in the parotid salivary gland, which is
accompanied by a decrease in the proportion of parenchyma and an increase in the area of the stroma of the gland.
Transmission electron microscopy revealed slagged erythrocytes in the MCR, pronounced apoptotic and destructive
changes in the parenchyma of the gland were observed. Against the background of vibration, concentrations of essential
elements Ca, Mg, Fe decreased and the content of Cu, Cd, Pb increased.
Conclusions.
Changes in the parotid salivary glands of the mother-fetus-offspring system during vibration are
manifested in a decrease in the area of the parenchyma, impaired saliva outflow, a decrease in the area of the vessels of
the MCR and an increase in the proportion of connective tissue. Deviations in mineral metabolism are a reflection of the
disturbed homeostasis of the mother-fetus-offspring system. The revealed changes are a morphofunctional basis, leading to a violation of the prenatal development of the parotid salivary glands of the fetus. The structural and biochemical
changes that occurred prenatally persist after birth in sexually mature offspring.
KEYWORDS: industrial vibration, mother-fetus system, salivary glands, mineral metabolism.
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