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Trace Elements in Medicine
International scientific and practical peer-reviewed journal
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T.Ya. Korchina, M.I. Sharifov, V.I. Korchin

Khanty-Mansiysk State Medical Academy
Mira st., 40, Khanty-Mansiysk, 628010, Russia



ABSTRACT. Purpose: to study the concentration in hair of trace elements involved in the pathogenesis of arterial hypertension in residents of Khanty-Mansiysk. Materials and methods. We examined 115 adult non-indigenous residents who have been living in the North for more than 10 years: 52 with a clinically confirmed diagnosis of arterial hypertension (AH): 24 men and 28 women and 63 donors without AH: 27 men and 36 women (40,5±8,2 years). The content of chemical elements in the hair was determined by AES-IP and MS-IP. Results. In patients with hypertension, lower concentrations of all studied trace elements were found, except for Fe: having a regulatory effect on blood pressure: Ca (M 1,3 and Me 1,5 times), Mg (p=0,007), K (p=0,023) and trace elements with antioxidant properties: Cu and Zn (1,1 times), Se (p<0,001) against the background of prooxidant properties of Fe (M=1,3 and Me=1,5 times) compared with similar parameters of the control groups. Conclusions: significantly worse availability of trace elements involved in the pathogenesis of hypertension, especially magnesium (p=0,001), potassium (p=0,023) and selenium (p<0,001) was found in patients with hypertension living in the North compared with patients without this pathology. Practical recommendations: to prepare a regional information array of data on the concentration of chemical elements in human trace substrates. This will help to predict, assess and manage the risks associated with a lack or excess of trace elements in humans at the personal and population levels; in order to increase the effectiveness and information saturation of occupational examination of the population, it is necessary to more widely introduce the study of the elemental composition of hair; along with traditional methods of preventing hypertension, it is necessary to correct the elemental status of patients in advance with the help of biologically active additives and micronutrient-enriched food products.

KEYWORDS: patients with arterial hypertension, Sever, trace elements, oxidative metabolism.