S.V. Notova1, E.V. Kiyaeva1,
T.V. Kazakova1, O.V. Marshinskaia1, D.V. Polyanitsa2
1Orenburg State University,
Institute of Bioelementology,
Prospect Pobedy, 13, Orenburg, 460018, Russia
2
ANO "Center for Biotic
Medicine",
Zemlyanoy Val str., d. 46, Moscow,
105064, Russia
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ABSTRACT. Type 2 diabetes and
its associated diseases have reached epidemic proportions. The total number of
adults with diabetes is projected to rise to 592 million in 2035, according to
a number of authors. Diabetes mellitus can lead to nephropathy, polyneuropathy,
retinopathy, cardiovascular disease, limb amputations, etc. The data available
in modern literature demonstrate the relationship of a number of chemical
elements with the characteristics of the course of type 2 diabetes mellitus. It
is known that trace elements are involved in numerous biochemical reactions, including
those associated with the metabolism of insulin and glucose. Violation of the
status of trace elements in diabetes mellitus can contribute to the development
of insulin resistance and the development of diabetic complications. On the
other hand, the progression of diabetes can lead to changes in the metabolism
of trace elements in tissues.
The purpose of this work is to analyze the available literature sources
on the features of zinc and copper metabolism in patients with type 2 diabetes
mellitus. The analysis of literature sources showed that the levels of zinc and
copper, diabetes mellitus and its complications not only correlate, but have a
complex relationship. To adequately address this issue, more research is needed
to improve our understanding of the role of these micronutrients in combating
oxidative stress and the prognosis of type 2 diabetes mellitus, as the results
available in the literature are still inconsistent.
KEYWORDS: type 2 diabetes
mellitus, trace elements, zinc, copper.