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Trace Elements in Medicine
International scientific and practical peer-reviewed journal
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S.V. Notova1, E.V. Kiyaeva1, T.V. Kazakova1, O.V. Marshinskaia1, D.V. Polyanitsa2

1Orenburg State University, Institute of Bioelementology,
Prospect Pobedy, 13, Orenburg, 460018, Russia

2 ANO "Center for Biotic Medicine",
Zemlyanoy Val str., d. 46, Moscow, 105064, Russia



ABSTRACT. Type 2 diabetes and its associated diseases have reached epidemic proportions. The total number of adults with diabetes is projected to rise to 592 million in 2035, according to a number of authors. Diabetes mellitus can lead to nephropathy, polyneuropathy, retinopathy, cardiovascular disease, limb amputations, etc. The data available in modern literature demonstrate the relationship of a number of chemical elements with the characteristics of the course of type 2 diabetes mellitus. It is known that trace elements are involved in numerous biochemical reactions, including those associated with the metabolism of insulin and glucose. Violation of the status of trace elements in diabetes mellitus can contribute to the development of insulin resistance and the development of diabetic complications. On the other hand, the progression of diabetes can lead to changes in the metabolism of trace elements in tissues.

The purpose of this work is to analyze the available literature sources on the features of zinc and copper metabolism in patients with type 2 diabetes mellitus. The analysis of literature sources showed that the levels of zinc and copper, diabetes mellitus and its complications not only correlate, but have a complex relationship. To adequately address this issue, more research is needed to improve our understanding of the role of these micronutrients in combating oxidative stress and the prognosis of type 2 diabetes mellitus, as the results available in the literature are still inconsistent.

KEYWORDS: type 2 diabetes mellitus, trace elements, zinc, copper.