A.A. Gubochkina, O.A. Legonkova
Bolshaya Serpukhovskaya, 27, 117997, Moscow, Russia
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ABSTRACT. The article
provides the analysis of the market state in the field of medical products in
the form of gels, pastes, granules and powders being registered on the
territory of the Russian Federation and used to fill bone defects. Despite on
conducted researches in this area, most of the bone substitutes are represented
by allo- and xenogenic materials: in total, they are 32% of the total number of
all medical products registered in the Russian Federation in the form of gels,
pastes, granules and powders. If we consider products produced by the Russian
manufacturers, 43% of the total amount are allo- and xenogenic materials.
Materials with functional additives (antibiotics and growth factors) are
presented in a small amount, i.e. 10% of the total number of all medical
devices registered in the Russian Federation. Attention is drawn to the fact
that, despite on the long-term practice of clinical use of auto-, allo- and
xeno-implants, none of them is the ideal material. Studies are underway on the
doses of microelements, rates of antibiotics in dependence on being chosen
composition (scaffold) with natural and synthetic polymers that influence a lot
on the effectivity of functional additives’ release. Synthetic polymers that
could be used as materials for tissue regeneration due to the great
possibilities for their modifications with the aim of getting the necessary
properties, are of special interest.
KEYWORDS: microelements, bone substitutes, bone implants,
tricalcium phosphate, hydroxyapatite, polylactide, polyglycolide, collagen.