L.L. Klimenko1,
A.V. Skalny2, A.N. Mazilina2,3
1
N.N. Semenov Institute of chemical physics in Russian Academy of Sciences,
Kosygina str., 4, Moscow, 119991, Russian Federation
2
Peoples Friendship University of Russia,
Mikluho-Maklaya str., 6, Moscow, 117198, Russian Federation
3 Hospital № 123
of FMBA of Russia,
Krasnogorsk highway, 15, Moscow region, Russian Federation
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ABSTRACT. The
literature review analyzes the results of modern studies of the role of macro-
and trace elements in the etiopathogenesis of ischemic stroke. The VEGF family
of neurospecific proteins is a vascular growth factor responsible for
angiogenesis and neurogenesis and has neuroprotective properties. The VEGF
protein line shares this role with an inorganic factor, metal-ligand
homeostasis. Macro- and trace elements are an integral part of the neurotrophic
system of the brain. A change in macro- and trace element balance is a
harbinger of the growing non-optimality of the CNS and a marker of neurotrophic
dysfunctions long before their clinical manifestations. In modern literature,
an analysis was made of the participation of a number of macro- and trace
elements in metabolic processes in the brain and their relationship with the
blood vessel growth factor VEGF during the formation of an ischemic focus.
Macro- and trace elements are a cofactor of antioxidant enzymes that protect
the brain from oxidative stress; they play a key role in dyscirculatory
diseases of the brain. The interaction of macro- and trace elements with the
neurospecific protein VEGF is a component of ischemic stroke endogenesis.
KEYWORDS: macro-
and trace elements, VEGF protein, angiogenesis.