A.A. Koroleva
I.M.
Sechenov First Moscow State Medical University (Sechenov University),
Trubetskaya
str., d. 8, p. 2, Moscow, 119991, Russian Federation
ANO
"Center for Biotic Medicine",
Zemlyanoy
Val str., d. 46, Moscow, 105064, Russian Federation
RUDN University,
Miklukho-Maklaya str., d. 6, Moscow, 117198, Russian Federation
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ABSTRACT. Manganese is one of the most important trace elements,
but it is important to know that excessive levels of Mn can cause neurotoxic
effects. To a greater extent, doctors and scientists are talking about how
toxic Manganese can affect the human body
with its significant excess in the elemental status of a person and what
consequences it can lead to. The study and understanding of the biology of
manganese, in particular at the level of cellular regulation, and most
importantly its role in neurological diseases, has growing interest. It is
indisputable, that manganese is an important trace element, which is necessary for the
activity of proteins (such as arginase and glutamine synthase). However, it is necessary to understand that
both deficiency and excess of Manganese may bring negative symptoms to a person. Manganese is inherently toxic
in excess. There are Manganese-dependent and Manganese-sensitive pathways associated with growing evidence of its
role in Parkinson's disease and Huntington's disease.
KEYWORDS: Manganese, Mn,
nervous system, Parkinson's disease, Huntington's disease.