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Trace Elements in Medicine
International scientific and practical peer-reviewed journal
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THE EFFECT OF MANGANESE ON THE NERVOUS SYSTEM: NEW RESEARCH

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A.A. Koroleva

I.M. Sechenov First Moscow State Medical University (Sechenov University),
Trubetskaya str., d. 8, p. 2, Moscow, 119991, Russian Federation

ANO "Center for Biotic Medicine",
Zemlyanoy Val str., d. 46, Moscow, 105064, Russian Federation

RUDN University,
Miklukho-Maklaya str., d. 6, Moscow, 117198, Russian Federation


 

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ABSTRACT. Manganese is one of the most important trace elements, but it is important to know that excessive levels of Mn can cause neurotoxic effects. To a greater extent, doctors and scientists are talking about how toxic Manganese can affect the human body with its significant excess in the elemental status of a person and what consequences it can lead to. The study and understanding of the biology of manganese, in particular at the level of cellular regulation, and most importantly its role in neurological diseases, has growing interest. It is indisputable, that manganese is an important trace element, which is necessary for the activity of proteins (such as arginase and glutamine synthase). However, it is necessary to understand that both deficiency and excess of Manganese may bring negative symptoms to a person. Manganese is inherently toxic in excess. There are Manganese-dependent and Manganese-sensitive pathways associated with growing evidence of its role in Parkinson's disease and Huntington's disease.

KEYWORDS: Manganese, Mn, nervous system, Parkinson's disease, Huntington's disease.