Версия сайта: English Russian
Trace Elements in Medicine
International scientific and practical peer-reviewed journal
Return back

TRACE ELEMENTS IN THE THERAPY AND PREVENTION OF CARDIOVASCULAR DISEASES

Download PDF

E.D. Namiot1*, G.D. Morozova1, A.A. Tsibulina2, I.I. Lapin1

1 I.M. Sechenov First Moscow State Medical University (Sechenov University),
Trubetskaya str., 8/2, Moscow, 119991, Russian Federation 

2ANO «Ctnter for Biotic medicine»,
Zemlyanoy Val str., 46, Moscow, 105064, Russian Federation

 

(Download)

ABSTRACT. Recently, there has been a significant increase in interest in studying the role of chemical elements in the development of various diseases, including cardiovascular. Due to the multifactorial nature and complex pathogenesis of cardiovascular diseases, it can be assumed that there is a connection between the levels of trace elements in the body and the risk of developing the disease. There is a lot of data on the role of zinc, copper, selenium, iron, and calcium in various mechanisms of hypertension, chronic heart failure, myocardial infarction, atherosclerosis, and insulin resistance. It is necessary to consider the clinical use of various trace elements, ways to assess the effectiveness of correction and detection of violations of elemental composition. Thus, in this work, direct clinical trials were considered, in which the elemental status appeared in one way or another in patients with CVD or having complications from the heart and blood vessels. One of the largest registers of clinical trials was used for the search clinicaltrials.gov. The search was performed using the words “Cardiovascular Disease” in the “Condition or disease” field and “trace elements”, “micronutrient”, “disorders”, “component” in the “other" field. Trials were maintained in which trace elements were used as an intervention and/or the elemental status was assessed against the background of cardiovascular pathologies. The final dataset included 104 clinical trials. Clinical trials were divided depending on the phase and status, and then based on the pathology studied. The study found that the largest number of clinical trials were aimed at preventing the development of cardiovascular diseases (26%). Acute coronary syndrome and diabetes were among the most frequently studied pathologies (17% and 12%, respectively). Among the most frequently studied elements, calcium (21%), chromium (10%), and selenium (10%) were isolated. The results indicate the prevalence of standard therapies in clinical practice, while the role of trace elements is often perceived as secondary. The researchers note a significant difference between the preclinical and clinical stages, which is due to inconsistency in assessing the effect of the new therapy, as well as criteria that cannot be extrapolated to real medical practice.

KEYWORDS: trace elements, cardiovascular diseases, arterial hypertension, serum, zinc, copper.