E.D. Namiot1, G.D.
Morozova1, M.V. Eremin2, A.R. Sadykov3, V.V. Yurasov3
1 I.M.
Sechenov First Moscow State Medical University (Sechenov University),
8/2, Trubetskaya str. Moscow, 119991, Russian Federation
2 ANO «Ctnter
for Biotic medicine»,
46, Zemlyanoy Val str., Moscow, 105064, Russian Federation
3 Clinical metabolomic laboratory,
65, Starokaluzhskoe sh.,
Moscow,117630, Russian Federation
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ABSTRACT. Fibrinogen is one of the key
participants in the coagulation cascade. Also, fibrinogen is able to act as a
pro-inflammatory agent. Recently, a hypothesis has been actively developed
about the special role of fibrinogen in the progression of the tumor process
and metastasis, including by stimulating the inflammatory response. Several
chemicals have pro-inflammatory/anti-inflammatory effects and their
relationship with fibrinogen is of particular interest. A literature review of
available studies and clinical trials on the relationship of fibrinogen with
various chemical elements was carried out in order to form a general
understanding of the mechanisms of this relationship. Interactions of
fibrinogen with iron, calcium, zinc, copper are considered in most detail. The continuation of the study of the interrelationships of the elemental
status with the indicators of inflammation is relevant.
KEYWORDS: fibrinogen,
iron, zinc, copper, calcium, inflammation, blood serum.