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Trace Elements in Medicine
International scientific and practical peer-reviewed journal
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E.D. Namiot1, G.D. Morozova1, M.V. Eremin2, A.R. Sadykov3, V.V. Yurasov3

1 I.M. Sechenov First Moscow State Medical University (Sechenov University),
8/2, Trubetskaya str. Moscow, 119991, Russian Federation

2 ANO «Ctnter for Biotic medicine»,
46, Zemlyanoy Val str., Moscow, 105064, Russian Federation 

3 Clinical metabolomic laboratory,

65, Starokaluzhskoe sh., Moscow,117630, Russian Federation



ABSTRACT.  Fibrinogen is one of the key participants in the coagulation cascade. Also, fibrinogen is able to act as a pro-inflammatory agent. Recently, a hypothesis has been actively developed about the special role of fibrinogen in the progression of the tumor process and metastasis, including by stimulating the inflammatory response. Several chemicals have pro-inflammatory/anti-inflammatory effects and their relationship with fibrinogen is of particular interest. A literature review of available studies and clinical trials on the relationship of fibrinogen with various chemical elements was carried out in order to form a general understanding of the mechanisms of this relationship. Interactions of fibrinogen with iron, calcium, zinc, copper are considered in most detail. The continuation of the study of the interrelationships of the elemental status with the indicators of inflammation is relevant.

KEYWORDS: fibrinogen, iron, zinc, copper, calcium, inflammation, blood serum.