T.V.
Korobeinikova1,2, G.D. Morozova1, D.V. Mak1,
A.M. Vishnevskaya1,2,
N.Kh. Kizima2, M.V. Eremin3
1
I.M. Sechenov First Moscow State Medical
University (Sechenov University),
8/2, Trubetskaya str., Moscow, 119991, Russian Federation
2
Peoples Friendship University of Russia,
6, Mikluho-Maklaya str., Moscow, 117198, Russian Federation
3ANO «Ctnter for Biotic medicine»,
46, Zemlyanoy Val str., Moscow, 105064, Russian Federation
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ABSTRACT. LIBS is a method of laser-induced breakdown spectroscopy that makes it
possible to determine the chemical consist of various substrates. The method
has both advantages and disadvantages compared to currently widely used methods
in diagnostics. The main advantage is that there is no need to decompose the
sample before analysis. However, LIBS has a low accuracy and detection limit.
The results obtained with LIBS are consistent with ICP-AES, ICP-MS for
macroelements as well as for toxic elements. The purpose of this review is to
form a general idea of the prospects for the use of LIBS in medicine in the
analysis of various biological substrates. To date, a number of works have been
published in which, using LIBS, the content of elements in solid biosubstrates
(nails, hair), liquid (whole blood, serum, urine), as well as in tumor tissues
was studied. The research results demonstrate the promise of using LIBS in the
diagnosis of various diseases and in screening. Further adaptation of this
method for the analysis of biosamples, improvement of calibration algorithms
and processing of the results are necessary.
KEYWORDS: LIBS, spectrometry, trace elements,
elemental status.