M.S. Alkhuseyn-Kulyaginova, A.M. Nikolaenko,
V.M. Kotieva, M.V. Gulyan, M.A. Dodokhova, I.M. Kotieva
Rostov State Medical
University,
Nakhichevan lane, 29, Rostov-on-Don, 344022, Russian Federation
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ABSTRACT. The search
for new national anticancer drugs is a priority purpose of interdisciplinary
biomedical research. So metal-containing compounds are the most promising group
of chemical compounds. The choice of metal and ligand grouping determines the
spectrum of the tested compounds’ pharmacological activity. The aim of the work
is to analyze the literature, which will show the problem of the drugs based on
tin compounds development. Literature search was carried out on the following
databases: Scopus, Web of Science, PubMed, eLIBRARY. Tin compounds have
different biological activity due to their chemical nature. Tin compounds have
different biological activity due to its chemical nature. The coordination
capabilities of the tin atom, i.e. its ability to form bonds with additional
ligands, have a significant impact on the degree, magnitude and selectivity of
the manifestation of antitumor and antimetastatic efficacy and toxic effects on
the body of tumor-bearing animals in preclinical studies in vivo.
Metal is necessary in the realization of the desired therapeutic effect.
Tin compounds have great biopharmaceutical potential for study in the field of
experimental oncology and microbiology.
KEYWORDS: tin,
metal-containing drugs, biopharmaceutical potential, malignant neoplasms.