Т.V.
Kazakova
Federal Research
Centre of Biological Systems and Agro-technologies of the RAS,
January 9 str., Orenburg, 460000, Russian Federation
(Download)
ABSTRACT. In
this study, the elemental composition of blood serum and cerebral cortex of
animals exposed to manganese during prenatal development was studied.
Materials and methods. For this purpose, non-pregnant Wistar rats have received a basic diet
with the addition of manganese salt at a dose of 1433 mg / kg / day during
prepregnancy (28 days) and gestation (20-23 days) periods. The blood and brain
sampling for determining the content of chemical elements by inductively
coupled plasma mass spectrometry was hold on the offspring aged 18 weeks.
Results. According
to the results of the study, an increase in the concentration of Mn and B was
found against the background of a decrease in K, Mg, Fe and Zn in the blood
serum, in the cerebral cortex – the accumulation of heavy metals Mn and Pb
against the background of a decrease in the concentrations of Fe, Se, Co and B.
Conclusion. These changes in the elemental profile of the body can become an
important link in the pathogenesis of certain diseases of the nervous system.
KEYWORDS: manganese,
macronutrients, trace elements, mineral metabolism,
mass spectrometry.