Centre of Biological Systems and Agro-technologies of the RAS,
January 9 str., Orenburg, 460000, Russian Federation
ABSTRACT. In this study, the elemental composition of blood serum and cerebral cortex of animals exposed to manganese during prenatal development was studied.
Materials and methods. For this purpose, non-pregnant Wistar rats have received a basic diet with the addition of manganese salt at a dose of 1433 mg / kg / day during prepregnancy (28 days) and gestation (20-23 days) periods. The blood and brain sampling for determining the content of chemical elements by inductively coupled plasma mass spectrometry was hold on the offspring aged 18 weeks.
Results. According to the results of the study, an increase in the concentration of Mn and B was found against the background of a decrease in K, Mg, Fe and Zn in the blood serum, in the cerebral cortex – the accumulation of heavy metals Mn and Pb against the background of a decrease in the concentrations of Fe, Se, Co and B.
Conclusion. These changes in the elemental profile of the body can become an important link in the pathogenesis of certain diseases of the nervous system.
KEYWORDS: manganese, macronutrients, trace elements, mineral metabolism, mass spectrometry.