V.V. Sofronov 1,
A.V. Voloshin 2, G.S. Skvortsova 2
1 Kazan
State Medical University of the Ministry of Health of the Russian Federation,
Butlerova str.
49, Kazan, 420012, Russian
Federation
2 Kazan
(Volga Region) Federal University of the Ministry of Education of the Russian
Federation,
Kremlyovskaya str.
18, Kazan,
420008, Russian Federation
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ABSTRACT. The aim of the study
was to isolate from a group of elements – copper, chromium, manganese,
selenium, magnesium, zinc, strontium – those whose concentration in blood
components (plasma and erythrocytes) can be used as markers for predicting the
pathology of newborns.
Materials
and methods. 98
pairs of full-term newborns and their mothers were under observation, including
58 pairs from the pathology department and 40 conditionally healthy pairs
(control comparison group). The concentration of chemical elements was carried out
by mass spectrometry with inductively coupled argon plasma. Statistical
processing, factor and component analysis of the obtained quantitative values
of the concentrations of elements in plasma and peripheral blood erythrocytes
were performed.
Results. Groups with extreme values of the
factor were identified. For each of the groups, the average indicators of
anamnestic data of women in labor and data on the clinical status of newborns
of the early neonatal period were determined. It was found that for the
"Factor I "-1" group, the concentrations of the elements
magnesium and copper in the blood of the mother and newborn are significantly
higher than the physiological norm, which leads to a decrease in the gestation
period and the weight of the newborn, an increase in the degree of intrauterine
development delay. In the case of the Factor II+1 group, the concentrations of
manganese and chromium are higher than the physiological norm, which mainly
leads to an increase in the likelihood of the pathology "Vegeto-visceral
disorders syndrome" in newborns.
Conclusions. As a marker of these pathologies, it
is possible to use a joint excess of the physiological norm of the
concentration of pairs of elements magnesium/ copper and manganese/chromium in
the blood components of pregnant women.
KEYWORDS: pathology, newborn, plasma, erythrocytes, parturient
woman, trace elements.