V.V. Sofronov 1, A.V. Voloshin 2, G.S. Skvortsova 2
State Medical University of the Ministry of Health of the Russian Federation,
Butlerova str. 49, Kazan, 420012, Russian Federation
(Volga Region) Federal University of the Ministry of Education of the Russian
Kremlyovskaya str. 18, Kazan, 420008, Russian Federation
ABSTRACT. The aim of the study was to isolate from a group of elements – copper, chromium, manganese, selenium, magnesium, zinc, strontium – those whose concentration in blood components (plasma and erythrocytes) can be used as markers for predicting the pathology of newborns.
Materials and methods. 98 pairs of full-term newborns and their mothers were under observation, including 58 pairs from the pathology department and 40 conditionally healthy pairs (control comparison group). The concentration of chemical elements was carried out by mass spectrometry with inductively coupled argon plasma. Statistical processing, factor and component analysis of the obtained quantitative values of the concentrations of elements in plasma and peripheral blood erythrocytes were performed.
Results. Groups with extreme values of the factor were identified. For each of the groups, the average indicators of anamnestic data of women in labor and data on the clinical status of newborns of the early neonatal period were determined. It was found that for the "Factor I "-1" group, the concentrations of the elements magnesium and copper in the blood of the mother and newborn are significantly higher than the physiological norm, which leads to a decrease in the gestation period and the weight of the newborn, an increase in the degree of intrauterine development delay. In the case of the Factor II+1 group, the concentrations of manganese and chromium are higher than the physiological norm, which mainly leads to an increase in the likelihood of the pathology "Vegeto-visceral disorders syndrome" in newborns.
Conclusions. As a marker of these pathologies, it is possible to use a joint excess of the physiological norm of the concentration of pairs of elements magnesium/ copper and manganese/chromium in the blood components of pregnant women.
KEYWORDS: pathology, newborn, plasma, erythrocytes, parturient woman, trace elements.