A.S. Sukharev,
A.V. Zinovieva, T.Ya. Korchina, V.I. Korchin, E.A. Ugorelova
Khanty-Mansiysk State Medical
Academy
Mira st. 40, Khanty-Mansiysk, 628010, Russian Federation
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ABSTRACT. The purpose of this work was to study the
correlation between biochemical indicators of bone metabolism and indicators of
bone mineral density in women of the northern region in the postmenopausal
period.
Materials and methods. We examined 169 women in the age range of 52-69 years old,
living in Khanty-Mansiysk for more than 10 years. The concentration of
parameters of bone destruction (parathormone, alkaline phosphatase,
β-CrossLaps) and bone formation (estrogen, vitamin D, Ca, Mg, P, Zn, Cu, Si,
Mn, vitamin D) was determined according to conventional methods.
Results. A deficiency of vitamin D concentration was established in 95,5% and
insufficiency of trace elements involved in the formation of bone tissue – 32,5-12,4% against the
background of an increase in bone resorption parameters – 26,6-3,6%.
Conclusion. The revealed direct statistically significant
relationships between the indicator of bone mineral density (BMD), the
provision of women with vitamin D and trace elements, as well as the inverse
relationship between BMD and bone destruction parameters indicate the
possibility of slowing down the development of osteoporosis by optimizing the
provision of postmenopausal women with vitamin D and trace elements.
KEYWORDS: postmenopausal
women, bone mineral density, vitamin D, trace elements.