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Trace Elements in Medicine
International scientific and practical peer-reviewed journal
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ASSOCIATION OF BONE METABOLISM PARAMETERS WITH BONE MINERAL DENSITY IN POST-MENOPAUSE WOMEN IN KHANTY-MANSIYSK

A.S. Sukharev, A.V. Zinovieva, T.Ya. Korchina, V.I. Korchin, E.A. Ugorelova

Khanty-Mansiysk State Medical Academy
Mira st. 40, Khanty-Mansiysk, 628010, Russian Federation

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ABSTRACT. The purpose of this work was to study the correlation between biochemical indicators of bone metabolism and indicators of bone mineral density in women of the northern region in the postmenopausal period.

Materials and methods. We examined 169 women in the age range of 52-69 years old, living in Khanty-Mansiysk for more than 10 years. The concentration of parameters of bone destruction (parathormone, alkaline phosphatase, β-CrossLaps) and bone formation (estrogen, vitamin D, Ca, Mg, P, Zn, Cu, Si, Mn, vitamin D) was determined according to conventional methods.

Results. A deficiency of vitamin D concentration was established in 95,5% and insufficiency of trace elements involved in the formation of bone tissue – 32,5-12,4% against the background of an increase in bone resorption parameters – 26,6-3,6%.

Conclusion. The revealed direct statistically significant relationships between the indicator of bone mineral density (BMD), the provision of women with vitamin D and trace elements, as well as the inverse relationship between BMD and bone destruction parameters indicate the possibility of slowing down the development of osteoporosis by optimizing the provision of postmenopausal women with vitamin D and trace elements.

KEYWORDS: postmenopausal women, bone mineral density, vitamin D, trace elements.