SPECIFIC PATTERNS OF TRACE ELEMENT STATUS OF ADULT YAROSLAVL INHABITANTS

A.L. Mazaletskaya¹, A.A. Skalny², E.P. Serebryansky³,
A.R. Grabeklis⁴, Yu.V. Zaitseva¹, E.A. Flerova^1,5, A.A. Tinkov^1,2

¹P.G. Demidov Yaroslavl State University,
Sovetskaya str. 14, Yaroslavl, 150003, Russian Federation

² Peoples Friendship University of Russia,

Mikluho-Maklaya str., 6, Moscow, 117198, Russian Federation
³Micronutrients Ltd., Perevedenovsky str. 13/8, Moscow, 105082, Russian Federation
⁴I.M. Sechenov First Moscow State Medical University (Sechenov University),

Trubetskaya str. 8/2, Moscow, 119991, Russian Federation
⁵Yaroslavl Scientific Research Center of Forage Production and Agroecology
– branch of the Federal Scientific Center "VIK named after V.R. Williams»
Yaroslavl 150003, Russian Federation

^(Download)

ABSTRACT. Objective – to investigate specific patterns of trace element status of adult inhabitants of Yaroslavl city.

Materials and Methods. A total of 178 occupationally unexposed adults aged from 20 to 80 years (99 men and 79 women) living in Yaroslavl were examined. In addition, examination of 113 adults (49 men and 64 women) living in a city with minor heavy industrial activities as a control group was performed. Assessment of hair trace element content was performed using inductively-coupled plasma mass spectrometry.

Results. When compared to the Russian reference values the examined subjects were characterized by increased incidence of toxic metal accumulation higher than 10% for cadmium, nickel, lead, tin, and especially aluminium
(> 20%). In turn, high incidence of low hair cobalt, copper, vanadium, and zinc content was observed. Further analysis demonstrated that hair aluminium, cadmium, nickel, and tin levels in Yaroslavl residents were 30%, 63%, 34%, and 28% higher as compared to the control location. Selenium and zinc content in subjects from Yaroslavl was 32% and 9% lower than the respective values in the control group, whereas hair V content was more than 2-fold lower. At the same time, adults living in Yaroslavl were characterized by 31% higher hair iron level.

Conclusions. Therefore, adults living in Yaroslavl city are characterized by increased accumulation of aluminium, cadmium, lead, tin and iron, in parallel with higher risk of zinc and vanadium deficiency. The revealed alterations of trace element status may at least partially contribute to development of environmental diseases of the population.

KEYWORDS: Yaroslavl, Central federal district, heavy metals, micronutrients, environmental diseases.