A.L. Mazaletskaya1, A.A. Skalny2,
E.P. Serebryansky3,
A.R. Grabeklis4, Yu.V. Zaitseva1, E.A. Flerova1,5,
A.A. Tinkov1,2
1P.G. Demidov Yaroslavl State
University,
Sovetskaya str. 14, Yaroslavl, 150003, Russian Federation
2
Peoples Friendship University of Russia,
Mikluho-Maklaya str.,
6, Moscow, 117198, Russian Federation
3Micronutrients Ltd., Perevedenovsky
str. 13/8, Moscow, 105082, Russian Federation
4I.M. Sechenov First
Moscow State Medical University (Sechenov University),
Trubetskaya str. 8/2, Moscow,
119991, Russian Federation
5Yaroslavl Scientific Research Center of Forage Production and
Agroecology
– branch of the Federal Scientific Center "VIK named after V.R. Williams»
Yaroslavl 150003, Russian Federation
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ABSTRACT. Objective – to
investigate specific patterns of trace element status of adult inhabitants of
Yaroslavl city.
Materials and Methods. A total of 178 occupationally
unexposed adults aged from 20 to 80 years (99 men and 79 women) living in
Yaroslavl were examined. In addition, examination of 113 adults (49 men and 64
women) living in a city with minor heavy industrial activities as a control
group was performed. Assessment of hair trace element content was performed
using inductively-coupled plasma mass spectrometry.
Results. When compared to the Russian reference values
the examined subjects were characterized by increased incidence of toxic metal
accumulation higher than 10% for cadmium, nickel, lead, tin, and especially
aluminium
(> 20%). In turn, high incidence of low hair cobalt, copper, vanadium, and
zinc content was observed. Further analysis demonstrated that hair aluminium,
cadmium, nickel, and tin levels in Yaroslavl residents were 30%, 63%, 34%, and
28% higher as compared to the control location. Selenium and zinc content in
subjects from Yaroslavl was 32% and 9% lower than the respective values in the
control group, whereas hair V content was more than 2-fold lower. At the same
time, adults living in Yaroslavl were characterized by 31% higher hair iron
level.
Conclusions.
Therefore, adults living in Yaroslavl city are characterized by increased
accumulation of aluminium, cadmium, lead, tin and iron, in parallel with higher
risk of zinc and vanadium deficiency. The revealed alterations of trace element
status may at least partially contribute to development of environmental
diseases of the population.
KEYWORDS:
Yaroslavl, Central federal district, heavy metals,
micronutrients, environmental diseases.