V.V. Yurasov1,
A.R. Sadykov1, G.D. Morozova2, E.D.
Namiot3, Yu.N. Lobanova4, V.L. Rejnyuk2
1 Clinical metabolomic laboratory,
Starokaluzhskoe rd. 65, Moscow, 117630, Russian Federation
2 Golikov Research Center of
Toxicology,
Bekhtereva str. 1, 192019, St. Petersburg, Russian Federation
3 I.M. Sechenov First Moscow State
Medical University (Sechenov University),
Trubetskaya str. 8/2, Moscow, Russian Federation
Peoples Friendship
University of Russia,
Mikluho-Maklaya str. 6, Moscow,
117198, Russian
Federation
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ABSTRACT. Metals play an
important role in the regulation of physiological processes, but can also have
potentially toxic effects on the human body. Nickel, silver, zirconium,
strontium are elements that in one way or another often contact with the skin
or mucous membranes. Determining the biocompatibility or potential toxicity of
materials is an insufficiently studied and relevant topic. The purpose of this
work was to study the relationship of nickel, silver, strontium, zirconium with
the C-reactive protein (as the marker of inflammation), as well as to establish
reference values of the concentrations of these elements in blood serum when
measured by the ICP-MS method. Correlations of concentrations of chemical
elements with the C-reactive protein in serum were considered. The study was
conducted using a database of laboratory tests of people aged 18 to 93 years.
The levels of nickel, silver, strontium, and zirconium in the blood serum were
analyzed by the ICP-MS method and the level of C-reactive protein by the
immunoturbidimetric method. Weak but statistically significant correlations of
silver (r = 0.138, p <0.001) and strontium (r = 0.166,
p <0.001) with C-reactive protein
were revealed in the general sample. When dividing the total sample by gender
and age, correlations of nickel, silver, zirconium, strontium concentrations
with C-reactive protein were observed among both men and women in the age group
of 36-45 years (p < 0.05). Thus, it was shown that
the effect of nickel, silver, strontium, and zirconium ions on the human body
is associated with an increased level of C-reactive protein in blood serum and
can have a pro-inflammatory effect.
KEYWORDS: nickel, silver, strontium, zirconium, inflammation, C-reactive protein.