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Trace Elements in Medicine
International scientific and practical peer-reviewed journal
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V.V. Yurasov1, A.R. Sadykov1, G.D. Morozova2, E.D. Namiot3, Yu.N. Lobanova4, V.L. Rejnyuk2

1 Clinical metabolomic laboratory,
Starokaluzhskoe rd. 65, Moscow, 117630,
Russian Federation

2 Golikov Research Center of Toxicology,
Bekhtereva str. 1, 192019, St. Petersburg,
Russian Federation

3 I.M. Sechenov First Moscow State Medical University (Sechenov University),
Trubetskaya str. 8/2, Moscow,
Russian Federation

Peoples Friendship University of Russia,
 Mikluho-Maklaya str. 6, Moscow, 117198,
Russian Federation


ABSTRACT. Metals play an important role in the regulation of physiological processes, but can also have potentially toxic effects on the human body. Nickel, silver, zirconium, strontium are elements that in one way or another often contact with the skin or mucous membranes. Determining the biocompatibility or potential toxicity of materials is an insufficiently studied and relevant topic. The purpose of this work was to study the relationship of nickel, silver, strontium, zirconium with the C-reactive protein (as the marker of inflammation), as well as to establish reference values of the concentrations of these elements in blood serum when measured by the ICP-MS method. Correlations of concentrations of chemical elements with the C-reactive protein in serum were considered. The study was conducted using a database of laboratory tests of people aged 18 to 93 years. The levels of nickel, silver, strontium, and zirconium in the blood serum were analyzed by the ICP-MS method and the level of C-reactive protein by the immunoturbidimetric method. Weak but statistically significant correlations of silver (r = 0.138, p <0.001) and strontium (r = 0.166,
p <0.001) with C-reactive protein were revealed in the general sample. When dividing the total sample by gender and age, correlations of nickel, silver, zirconium, strontium concentrations with C-reactive protein were observed among both men and women in the age group of 36
-45 years (p < 0.05). Thus, it was shown that the effect of nickel, silver, strontium, and zirconium ions on the human body is associated with an increased level of C-reactive protein in blood serum and can have a pro-inflammatory effect.

KEYWORDS: nickel, silver, strontium, zirconium, inflammation, C-reactive protein.