Trace Elements in Medicine (Moscow)
2022, 23(1): 41-46
ORIGINAL PAPERS

STUDY OF THE RELATIONSHIP OF TIN AND ANTIMONY CONCENTRATIONS WITH THE CRP IN BLOOD SERUM

V.V. Yurasov¹, G.D. Morozova¹, A.R. Sadykov², E.D. Namiot², Almasry Rasha³, Yu.N. Lobanova³

¹FSBI "Scientific and Clinical Center of Toxicology named after S.N. Golikov FMBA of Russia" 1, Bekhtereva str., 192019, St. Petersburg, Russia
²I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2, Trubetskaya str., Moscow, Russia
³Peoples Friendship University of Russia, 6, Mikluho-Maklaya str., Moscow, 117198, Russia

DOI: 10.19112/2413-6174-2022-23-1-41-46 

ABSTRACT. The study of the effect of toxic metals on the development of pathological states is an important and necessary area of research. Antimony and tin, being toxic metals, can have undesirable effects on the human body and cause the further development of diseases. The purpose of this study was to investigate the possible effect of tin and antimony on the development of inflammatory reactions. Correlations between the concentrations of these elements and the levels of C-reactive protein in blood serum (as the main marker of inflammation) were evaluated. Reference values of serum tin and antimony concentrations were also calculated using the Hoffman method. The study was conducted on the basis of laboratory tests of people aged 18 to 80 years. The levels of tin and antimony were analyzed by the ICP-MS method, as well as the level of C-reactive protein by the immunoturbidimetric method in the blood serum. The study revealed that antimony has weak but statistically significant correlations with C-reactive protein (r < 0.200, p < 0.01) both in the general sample and among men and women separately. When dividing by age in the group of people from 18 to 25 years old, corre-lations with C-reactive protein were observed in both antimony and tin. In this case, antimony showed negative correlations (p < 0.05), and tin - positive ones (p < 0.05). The results obtained indicate that the concentrations of tin and antimony in the blood serum are not specific markers of the inflammatory process, but they should be taken into account when examining patients in contact with these metals in order to prevent the development of various pathological processes.

KEYWORDS: tin, antimony, CRP, ICP-MS, toxic metals, inflammation, pathology.