Trace Elements in Medicine (Moscow)
2018, 19(3): 37-40
ORIGINAL PAPERS

DAILY VARIABILITY OF SALIVARY TRACE ELEMENT IN HEALTHY WOMEN'S

I.V. Radysh, T.N. Umnova, V.V. Skalny, V.I. Torshin, B.B. Radysh, A.E. Severin

Peoples' Friendship University of Russia, Miklukho-Maklaya str. 6, Moscow, 117198, Russia

DOI: 10.19112/2413-6174-2018-19-3-37-40 

ABSTRACT. The aim is to study the circadian concentration of macro- and trace elements of whole saliva in healthy women of reproductive age. 206 practically healthy women in the follicular phase on day 68 and the midluteal for 1922 days of the menstrual cycle aged 2042 years were examined. Analytical determination of the content of macro- and trace elements in whole saliva has been carried out using ICP-AES and ICP-MS methods. It has been established that the maximum concentration of Ca and Na are in the morning, and K, Li, Mg, P and Zn are evening ones, regardless of the phases of the menstrual cycle. Daily differences are statistically significant (p < 0.05). Mean daily concentrations of Ca, Na and Zn are significantly higher in the follicular phase, and Li, K, Mg and P - in midluteal (p < 0.05). The Spearman range correlation analysis showed that an inverse correlation was established between Li and Na concentrations: in the morning in the follicular phase (r = -0.49, p < 0.001) and in the midluteal (r = -0.71, p < 0.001); in the evening (r = -0.59, p < 0.001) and (r = -0.78, p < 0.001), respectively. Thus, the revealed changes in the chronostructure of the circadian dynamics of macro- and trace elements excretion in healthy women of reproductive age testify to the phenomenon of daily and monthly rhythmicity.

KEYWORDS: whole saliva, circadian rhythm, macro- and trace elements, menstrual cycle.