Trace Elements in Medicine (Moscow)
2018, 19(3): 37-40
DAILY VARIABILITY OF SALIVARY TRACE ELEMENT IN HEALTHY WOMEN'S
I.V. Radysh, T.N. Umnova, V.V. Skalny, V.I. Torshin, B.B. Radysh, A.E. Severin
Peoples' Friendship University of Russia, Miklukho-Maklaya str. 6, Moscow, 117198, Russia
ABSTRACT. The aim is to study the circadian concentration of macro- and trace elements of whole saliva in healthy women of reproductive age. 206 practically healthy women in the follicular phase on day 68 and the midluteal for 1922 days of the menstrual cycle aged 2042 years were examined. Analytical determination of the content of macro- and trace elements in whole saliva has been carried out using ICP-AES and ICP-MS methods. It has been established that the maximum concentration of Ca and Na are in the morning, and K, Li, Mg, P and Zn are evening ones, regardless of the phases of the menstrual cycle. Daily differences are statistically significant (p < 0.05). Mean daily concentrations of Ca, Na and Zn are significantly higher in the follicular phase, and Li, K, Mg and P - in midluteal (p < 0.05). The Spearman range correlation analysis showed that an inverse correlation was established between Li and Na concentrations: in the morning in the follicular phase (r = -0.49, p < 0.001) and in the midluteal (r = -0.71, p < 0.001); in the evening (r = -0.59, p < 0.001) and (r = -0.78, p < 0.001), respectively. Thus, the revealed changes in the chronostructure of the circadian dynamics of macro- and trace elements excretion in healthy women of reproductive age testify to the phenomenon of daily and monthly rhythmicity.
KEYWORDS: whole saliva, circadian rhythm, macro- and trace elements, menstrual cycle.Corresponding author: I.V. Radysh E-mail: firstname.lastname@example.org