Supplement to the journal
"Trace Elements in Medicine" (Moscow)
2021: 22-25

AGE-CAUSED CHANGE OF THE MICROELEMENT PROFILE OF LYMPH NODES OF DIFFERENT LOCALIZATION

V.N. Gorchakov¹*, Yu.P. Kolmogorov², O.V. Gorchakova²

¹Novosibirsk State University
²Research Institute of clinical and experimental Lymphology – branch of Institute of Cytology and Genetics of the Siberian Branch of The Russian Academy of Science

DOI: 10.19112/2413-6174-2021-S1-10 

ABSTRACT. The purpose is a research of content of microelements in regional lymph nodes in view of localization and age. Microelements defined with the help X-ray fluorescent analysis with use of synchrotron radiation. The microelement profile of lymph nodes has the region-dependent character, reflecting an originality of the lymphatic region. Distinctions of microelements content are recorded for each of regional lymph nodes. The mesenteric lymph node has the maximum maintenance of Cu, Se, an average – Fe, Zn, minimum – Mn. The tracheobronchial lymph node is characterized by the smallest maintenance of Fe, Cu, Zn, an average – Mn, Se. The inguinal lymph node distinguishes the maximum content of Mn, Fe, Zn, an average – Cu, minimum – Se. When aging the microelement profile of lymph nodes changes, showing reduction of content of the majority of microelements at increase in Mn. Qualitatively new microelement profile is formed in each of lymph nodes when aging. It reflects decrease in drainage and immune function of lymph nodes at the scarce level of bioelements. With age in the inguinal lymph node rather high rates of content of Mn, Fe, Zn and the smallest take place for Cu and Se. The mesenteric lymph node distinguishes high value of concentration Se, an average – Cu, Zn and low – Mn, Fe. The tracheobronchial lymph node is characterized by low value of contents Zn, an average – Mn, Fe, Se and high – Cu. The received results prove regional specifics of microelement balance of lymph nodes depending on the region and age.

KEYWORDS: trace elements, lymph nodes, ontogenesis, gerontology.