Supplement to the journal
"Trace Elements in Medicine" (Moscow)
2021: 12-14

THE EFFECT OF Cu AND CuO NANOPARTICLES ON DANIO RERIO ANTIOXIDANT SYSTEM

E.P. Miroshnikova, A.E. Arinzhanov*, Y.V. Kilyakova

Orenburg State University

DOI: 10.19112/2413-6174-2021-S1-04 

ABSTRACT. The article presents the results of the nanoparticles (NP) effect of Cu (purity 99.7%, d = 55 nm) and CuO (purity 99.6%, d = 90 nm) obtained by plasma chemical synthesis on the Danio rerio survival and antioxidant system, at concentrations of 0.001 mg/dm³, 0.01 and 0.1 mg/dm³. It was established that the nanoparticles intake into the Daniorerio body is accompanied by the fish death with a subsequent progressive decrease in survival with an increase in exposure time (up to 84 days). The studied nanoparticles cause a decrease in antioxidant defence (catalase, superoxide dismutase) of fish body against the background of oxidative stress. The content of malonic dialdehyde increases by the end of the experiment by 8 times (NP Cu – 0.001 mg/dm³), by 42 times (NP Cu – 0.01 mg/dm³), by 3.5 times (NP Cu – 0.1 mg/dm³) and by 2 times (NP CuO– 0.001 mg/dm³, 0.01 and 0.1 mg/dm³).

KEYWORDS: copper, nanoparticles, survival, toxicity, Daniorerio.