Trace Elements in Medicine (Moscow)
2020, 21(3): 43-49
ORIGINAL PAPERS

MÖSSBAUER SPECTROSCOPY OF FERROUS FUMARATE IN PHARMACEUTICAL PRODUCT USED TO TREAT ANEMIA

F.G. Vagizov, J. Nicolas Pineda M.

KFU (Kazan (Volga Region) Federal University), Kremlevskaya 18, Kazan, 420 008, Republic of Tatarstan, Russia

DOI: 10.19112/2413-6174-2020-21-3-43-49 

ABSTRACT. The World Health Organization (WHO) considers iron deficiency anemia a serious public health problem in developing countries and recommends the use of iron tablets containing iron II for prevention and treatment. The results of Mössbauer measurements of the drug “Ferretab”, which is widely used in medicine for the treatment and prevention of iron deficiency anemia, are presented. This drug contains fumarate iron, C₄H₂FeO₄, and has a small amount of folic acid. In this paper, the temperature dependence of isomer shift and quadrupole splitting values of ⁵⁷Fe nuclei in iron fumarate were studied. The measurements show that when the temperature increases, the isomer shift and quadrupole splitting of ⁵⁷Fe nuclei in iron fumarate decreases, the decrease in the isomer shift value is associated with the second-order Doppler effect. Based on Mössbauer measurements, the Debye temperature of this drug was determined. The Debye temperature gives us information about the strong bonding of ⁵⁷Fe atoms with the environment. A high temperature value means a strong bond and vice versa, a small temperature value means a bond with low rigidity. The coupling constant (Debye temperature) defined for “Ferretab” iron nuclei has been compared with different Debye temperatures found in previous studies on some iron deficiency anemia drugs. Additionally, the values were compared with various clinical studies conducted in in-vivo and in-vitro for comparison of the efficacy of some of the most commonly used drugs to treat and prevent iron deficiency anemia. According to these comparisons, it was established a possible relationship between the Debye temperature of the iron atoms of the drugs under study and their effectiveness. It was noted that the lower the Debye temperature of iron atoms of the drug, the more iron absorbs the human body.

KEYWORDS: Mössbauer measurements, iron deficiency anemia, isomer shift, quadrupole splitting, second-order Doppler effect, antianemic drugs, Debye temperature.