Trace Elements in Medicine (Moscow)
2020, 21(3): 3-23
TOPICAL PAPERS

ANTIVIRAL, ANTIOXIDANT AND CATALYTIC ACTIVITY OF TRACE ELEMENTS IN A LOW DEGREE OF OXIDATION

M.Y. Spivak¹, V.G. Kaplunenko ², M.V. Kosinov², A.V. Skalny³

¹ Zabolotny Institute of microbiology and virology, National Academy of Sciences of Ukraine, st. Academician Zabolotny, 154, Kiev, 03143, Ukraine
² Nanomaterials and Nanotechnologies LTD, st. Vasylkivska, 27, Kiev, 03022, Ukraine
³ First Sechenov Moscow State Medical University, 19c1, Bolshaya Pirogovskaya Street, Moscow, 119146, Russia; Peoples Friendship University of Russia, Mikluho-Maklaya str., 6, Moscow, 117198, Russia

DOI: 10.19112/2413-6174-2020-21-3-3-23 

ABSTRACT. The review article studies the role of trace elements in protecting the body from viruses and focuses on the high antiviral activity of trace elements, which they exhibit if they are in a low degree of oxidation. Trace elements in a degree of oxidation make it possible to create new generation of antiseptics safe for humans. Has been discovered the mechanism of antiviral action of trace elements in a low degree of oxidation based on the suppression of electrostatic Coulomb interaction of virus with the cell. Sanitizers of a new generation can become effective prophylactic means for protecting the body from infection COVID-19 due to the fact that a vaccine against the SARS-CoV-2 coronavirus is under development, and there are no direct drugs for it. Compositions of substances for pharmaceutical use based on antimicrobial trace elements in a low degree of oxidation, which can be used either directly or as raw materials for production of drugs against the SARS-CoV-2 coronavirus, are given. Aqueous solutions of trace element sanitizers are suitable for inhalation and intranasal application and can be used in the form of aerosol or spray for throat and nose or eye drops at the first symptoms of disease, as well as at high risks of infection.

KEYWORDS: low degree of oxidation, anti-virus trace elements, COVID-19, SARS-CoV-2, anti-virus substances, antioxidant, electrostatic interaction, virus inactivation on mucous membranes.