Trace Elements in Medicine (Moscow)
2017, 18(4): 22−29
ORIGINAL PAPER

PECULIARITIES OF THE EFFECT OF WATER ENRICHED WITH «JODIS CONCENTRATE» ON ANIMALS UNDER THE COMBINED EFFECT OF IRRADIATION AND STRESS

V.N. Melnichenko 2, V.I. Maksin 1, A.P. Yaroshchuk 3

1 National University of Life and Environmental Sciences of Ukraine, Geroev Oborony str. 15, Kiev 03041, Ukraine
2 LTD Science manufacture company «Iodis», prosp Pobedy 104-Б, Kiev 03115, Ukraine
3 International concern «Yark-Kiev», prosp Pobedy 104-Б, Kiev 03115, Ukraine

DOI: 10.19112/2413-6174-2017-18-4-22-29 

ABSTRACT. The influence water enriched with «Jodis concentrate» on the daily water intake in dozes of 20 and 100 μg/kg animal weight of mature rats in combination with irradiation and stress was studied. The examined product demonstrated the possibility to normalize the activity of marker enzymes aspartate aminotransferase and alkaline phosphatase, which was increased in the result of irradiation and stress action. Ultimately the metabolism normalization promoted the optimization of blood clotting duration and testosterone level which were disturbed in the result of radiation and stress in blood of lab rats. It is possible that the normalizing influence factor is connected with antioxidant activity of examined product based on the data on normalization of malondialdehide and catalase level in blood serum, as well as increasing of erythrocyte membrane resistance to the action of hemolytic agent. . Increasing of Blood Catalase Activity due to the increase of adrenaline in the blood and the formation of hydrogen peroxide occurs under combined exposure to radiation and stress. At the same time, a decrease in the amount of hemoglobin in the blood is observed. Increased catalase activity and decreased hemoglobin levels in the blood were not observed in rats with enriched iodine water diet. That’s why drinking water based on "Jodis-concentrate" of the can be used for enrichment of food and animal feed products under unfavourable ecological influence.

KEYWORDS: drinking water, product «Jodis-concentrate», radiation, stress, the membrane of red blood cells, lipid peroxidation, the dose