Trace Elements in Medicine (Moscow)
2016, 17(4): 27-33
ORIGINAL PAPER

EVALUATION OF TRACE ELEMENTS CONTENT IN «MOTHER-PLACENTA-FETUS» SYSTEM IN EXPERIMENTAL MODELLING OF PASSIVE SMOKING

S.V. Notova 1,2, E.V. Kiyaeva 1, L.V. Lizyrchik 1, S.S. Akimov 1

1 Orenburg State University, Pobedy ave., 13, Orenburg 460018, Russia
2 All-Russian Research Institute of Beef Cattle Breeding, 9 Yanvarya str. 29, Orenburg 460000, Russia

DOI: 10.19112/2413-6174-2016-17-4-27-33 

ABSTRACT. The article presents the results of research on the effect of passive smoking on trace elements content in «motherplacentafetus» system in the experiment. The objects of study were Wistar rats (age 67 mo, body wt 200 ± 10 g, n = 40) and their fetuses. In the first accounting period the rats were non-pregnant, in the second one - pregnant. The study on the establishment of reproductive toxicity and embryotoxicity of tobacco smoke was conducted through exposure of rats to smoke atmosphere («secondhand smoke» model) in an exposure chamber. Samples of lung, liver, bone and placenta were used to study elemental status of the animals. Average sample was formed to study the elemental composition of the fetus. The study revealed that secondhand smoke affected the balance of chemical elements in the «motherplacentafetus» system. Thus, at the end of the first accounting period of the experiment in the lung tissue of animals of the experimental group the content of As significantly increased and the concentration of Ca, Mn, and Zn decreased. On the contrary, in liver tissue a significantly higher content of Ca, Mn, Zn was detected. In bone tissue lower amounts of Ca were found. During gestation period the passive smoking had maximal impact on the elemental status of animal organism: in lung tissue statistically higher levels of As, Cd and lower levels of Ca, Co, Cr, Mn were observed. In the liver higher levels of Ca and lower levels of Cd were revealed. In the bones lower contents of Zn was found. In placenta of animals of the experimental group the level of Cd was higher. In fetuses of experimental groups there were observed statistically higher levels of Cr, Mn, Se, Zn, Cd and a lower level of Са.

KEYWORDS: pregnancy, passive smoking, nicotine, embryotoxicity, trace elements.