TRACE ELEMENTS IN MEDICINE (MOSCOW)
2015. 16(4): 45-50
ORIGINAL PAPERS

SELENOCYSTINE SYNTHESIS AND PROSPECTS OF ITS UTILIZATION IN CORRECTION OF SELENIUM DEFICIENCY

P.A. Poluboyarinov*

Penza State University of Architecture and Construction, Germana Titova str. 28, Penza, 440028, Russia

DOI: 10.19112/2413-6174-2015-16-4-45-50 

ABSTRACT. Inorganic compounds of selenium, selenium fortified yeast and selenium containing xenobiotics widely used for correction of selenium deficiency in domestic animals and human beings possess several serious drawbacks. L-selenocysteine (an oxidized form is selenocystine) demonstrating full physiological compatibility, anticancerogenic, antiradical, immunomodulating and protective functions is a prospective compound both for correction of selenium deficiency and biological activity. L-selenocystine synthesis was developed in Penza agricultural academy (Pat. RF №2537166). Capillary electrophoresis of the compound revealed the identity with Sigma L-selenocystine. To demonstrate potential abilities of L-selenocystine an experiment was achieved on broilers cross “Ross 308”. Utilization of 0.3 g Se/t of feed (as a selenocystine) with OMEC premix resulted in 1.35 % increase of broilers biomass and a 0.88 % reduced cost of feed compared to control group and a group of broilers with selenite consumption (Se – 0.3 g/t). Analysis of selenium content in cnemis revealed that 0.3 g Se/t of selenocystine increased cnemis selenium content up to 0.24 mg/kg  the same as in the group with sodium selenite (Se  0.3 g/t) being 0.07 mg/kg greater than in the control group.

KEYWORDS: selenium, selenocystine, synthesis, capillary electrophoresis, broilers, growth promotihg effect, daily weight gains.