TRACE ELEMENTS IN MEDICINE (MOSCOW)
2015. 16(2): 37-41
ORIGINAL PAPERS

FORMATION OF HEMATOLOGICAL EFFECTS IN CONDITIONS OF CHRONIC IRRADIATION AND INTOXICATION WITH HEAVY METALS

S.N. Sushko, S.V. Goncharov, N.D. Puzan

The Institute of Radiobiology NASB, Fedyuninskogo str. 4, Gomel, 246007, Gomel region, Belarus

DOI: 10.19112/2413-6174-2015-16-2-37-41

ABSTRACT. In an experiment on Af mice, the effects of living in the area of Chernobyl accident during 60 days on hemopoietic system with consequent chronic intoxication by copper and cadmium was studied. The chronic irradiation decreased the level of erythrocytes and hemoglobin, increased spleen mass. Watering with salts of these metals for 45 days had no effect on spleen weight in intact animals, while it caused an increase in the spleen index in irradiated mice. The use of CdCl2 reduced significantly a number of erythrocytes in intact mice; СuSO4 did the same (and reduced hemoglobin) in chronically irradiated animals. The 60-day exposure in the hazardous area had no effect on the level of MetHb. After intoxication by the metals within 45 days its increase was observed in intact mice, being statistically significant and more expressed after intoxication by copper. The exposure in the alienation zone, as well as reception of CdCl2 and СuSO4 solutions, did not significantly affected the total and effective albumin concentration; a significant decrease in these parameters was detected after combined action of these factors and caused the most violent disorders of the albumin transport system. In the experiment for the studied hematological parameters, the effects of the combined action of the ecological factors were contradictory; this may be due to the toxicokinetics of these metals.

KEYWORDS: chronic irradiation, copper, cadmium, hemoglobin, methemoglobin, serum albumin.