ABSTRACT. The aim of this study was to determine the microelement composition of bone tissue in patients with severe hip pathology living in the Trans-Baikal Territory.
Materials and Methods. Twenty-one patients were examined, including 11 (52.4%) men and 10 (47.6%) women who had undergone total hip arthroplasty. The average age of the patients was 58.6 years. The nosological entities represented idiopathic coxarthrosis and aseptic necrosis of the femoral head. Microelement content was determined using total external reflectance X-ray fluorescence analysis.
Results. The study revealed a significant imbalance in the microelement composition of bone tissue in patients with idiopathic coxarthrosis and aseptic necrosis. Mean levels of titanium (Ti), chromium (Cr), manganese (Mn), iron (Fe), copper (Cu), zinc (Zn), bromine (Br), strontium (Sr), and lead (Pb) were below the reference values for average dry bone tissue. The most significant decreases (2-5 times) were observed for Cr, Br, Pb, Ti, Fe, Zn, and Sr. In contrast, cobalt (Co) levels were 4.2 times higher than the reference value. Statistical analysis using the Mann-Whitney U test revealed no significant differences with one literature source (U = 55, p = 0.34), indicating high variability in microelement composition.
Conclusions. The study identified specific microelement imbalances in bone tissue in patients who underwent hip arthroplasty. The identified deficiency of essential elements (Zn, Sr, Cu) and pathological accumulation of Co may play a role in the pathogenesis of degenerative joint changes and should be considered when developing comprehensive rehabilitation and preventive measures for this category of patients.
KEYWORDS: bone tissue microelement composition, X-ray fluorescence analysis, hip joint.
For citation: Bondarevich E.A., Dordzheev V.V., Shitin V.S., Staritsyn A.F. Analysis of microelement composition of bone tissue in elderly patients with hip joint pathology. Trace elemets in medicine. 2026;27(1):52-56. DOI: 10.19112/2413-6174-2026-27-1-52-56
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Information about the authors:
E.A. Bondarevich – Ph.D. (Biol.), Associate Professor,
Associate Professor of the Department of Chemistry and Biochemistry;
ORCID: 0000-0002-0032-3155; SPIN: 2664-0626
V.V. Dordzheev – Ph.D. (Med.), Associate Professor,
Associate Professor of the Department of Traumatology and Orthopedics;
ORCID: 0000-0002-3324-658X; SPIN: 8223-4195
V.S. Shitin – Resident Physician of the Department of Traumatology and Orthopedics
A.F. Staritsyn – Resident of the Department of Traumatology and Orthopedics
Conflict of interest
The authors declare no obvious and potential conflicts of interest related to the publication of this article.
