ABSTRACT.
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world, in which
there is excessive accumulation of fat in the liver in the absence of significant alcohol consumption. Essential trace elements are structural components of many biologically active substances in the body and influence the metabolic processes. In this work, we analyzed the results of studies on the role of essential trace elements in the pathogenesis of
NAFLD. Zinc, copper, manganese, selenium participate in antioxidant defense of the organism; they influence carbohydrate and fat metabolism. The influence of iron metabolism on glucose and lipid metabolism is characterized by a
complex and dynamic bidirectional relationship. Disruption of iron distribution contributes to the development of metabolic pathologies including fatty hepatosis. According to the literature, zinc deficiency, selenium excess, copper, manganese and iron metabolism disorders, both in the deficiency and excess sides, are associated with NAFLD.
KEYWORDS: NAFLD, inflammation, zinc, copper, trace elements