ABSTRACT.
The paper presents the results of an elemental analysis of tissues and an assessment of the metabolic
pools of chemical elements in the brain of animals for 25 chemical elements and established a violation of the mineral
metabolism of both toxic and essential and macronutrients when chromium asparaginate is included in the diet. Experimental studies were carried out on 80 white male Wistar rats weighing 110-120 g. The drug was administered per os,
kneaded into the feed before serving to animals on a standard diet. In accordance with the manufacturer's recommendations and the daily requirement of the body for chromium, we formed groups receiving chromium asparaginate in dosages corresponding to 100% of the need, 50% lower and 50% higher than the daily requirement for this element, while
chromium doses were 1.1, 0.6 and 1.7 mg/kg. In animals receiving chromium asparaginate in addition to the diet, a decrease in the concentration of macro-essential elements was observed in the hippocampus, however, the elimination of
toxic elements, in particular with regard to tin and cadmium, was also noted. In the brain of rats, the accumulation of iodine, silicon and magnesium was noted when various doses of chromium were turned on. Thus, the data obtained as a
result of the study indicate the redistribution of chemical elements in the hippocampus of laboratory animals under conditions of additional introduction of the organic form of chromium into the diet of laboratory animals.
KEYWORDS: chromium, asparaginates, elemental metabolism, brain, rats.