ABSTRACT.
The paper presents the results of studies of the prooxidant effect of titanium ultradisperse particles (UDP) at high dosages (0.06-6 mg/dm3 ). Danio rerio fish were used as a test subject. On the 14th day of the experiment a decrease in malonic dialdehyde (MDA) content was observed. Increasing the exposure time resulted in increased MDA production, as well as a decrease in superoxide dismutase (SOD) activity in all groups compared to the beginning of the experiment, but at the same time in the experimental groups SOD was higher than the control by 2.5 times. Analysis of catalase activity showed its significant increase during the whole period of exposure in all experimental groups compared to the control, and at the end of the experiment the maximum activity of catalase was recorded, which can be considered as an adaptive response of the organism to the development of oxidative stress, which confirms the toxic effect of UDP Ti at high doses.
KEYWORDS: titanium, ultrafine particles, toxicity.