L.V. Lizyrchik
Regional
Clinical Hospital № 2 Perinatal Centre,
Nevelskaya str., 24, 460000,
Orenburg, Russia
ABSTRACT. The
aim of the research was to study the interconnection between the elemental
composition and morphofunctional characteristics of the rat placenta during the
tobacco intoxication. Determining the elemental composition of the placenta was
performed using an Elan 9000 mass spectrometer and an Optima 2000 V atomic
emission spectrometer. The morphofunctional characteristics of the placenta
were studied by preparing the serial paraffin histological sections. Data processing
was performed using the Mann-Whitney U-test. It was established that as the
result of a passive smoking, the fertility of females decreased, the physical
development of fetuses also decreased, the weight and thickness of the placenta
declined, the number of fetal capillaries and maternal sinuses of the placenta
decreased. The most common pathological changes in the histological structure
of the placentas of the experimental groups were the development of foci of
circulatory disorders, inflammatory and atrophic changes. When comparing the
elemental composition of the experimental groups, lower values of magnesium and
iron were found, against the background of higher values of lead and cadmium.
Identified dislementasis in conjunction with the pathological changes in the
placenta caused a placental insufficiency, which in turn led to the delay in
fetal development of the fetus.
KEYWORDS: passive smoking, toxic trace elements, essential trace
elements, rats.