Supplement to the journal
"Trace Elements in Medicine" (Moscow)
THE INFLUENCE OF GLUTATHIONE-CONTAINING DINITROSYL IRON COMPLEXES ON BLOOD OXIDATIVE METABOLISM IN RATS
A.K. Martuseivch, A.G. Soloveva, L.K. Kovaleva
Privolzhsky Research Medical University, Nizhny Novgorod, Russia
Kuban State Medical University, Krasnodar, Russia
ABSTRACT. We studied the influence of dinitrosyl iron complexes (DNIC) on oxidative metabolism in rats’ blood. The intensity of lipid peroxidation, antioxidant activity and malonic dialdehyde level were estimated in blood samples from rats, treating with injections of saline (control) or saline with 0.15; 0.30; 0.45 and 0.60 мМ of DNIC. Our results demonstrated that DNIC has antioxidant properties. This effect is dose-dependent with optimum in 0.3–0.45 mM.
KEYWORDS: blood, oxidative metabolism, dinitrosyl iron complexes.