Supplement to the journal
"Trace Elements in Medicine" (Moscow)
THE EFFECT OF Cu AND CuO NANOPARTICLES ON DANIO RERIO ANTIOXIDANT SYSTEM
E.P. Miroshnikova, A.E. Arinzhanov*, Y.V. Kilyakova
Orenburg State University
ABSTRACT. The article presents the results of the nanoparticles (NP) effect of Cu (purity 99.7%, d = 55 nm) and CuO (purity 99.6%, d = 90 nm) obtained by plasma chemical synthesis on the Danio rerio survival and antioxidant system, at concentrations of 0.001 mg/dm3, 0.01 and 0.1 mg/dm3. It was established that the nanoparticles intake into the Daniorerio body is accompanied by the fish death with a subsequent progressive decrease in survival with an increase in exposure time (up to 84 days). The studied nanoparticles cause a decrease in antioxidant defence (catalase, superoxide dismutase) of fish body against the background of oxidative stress. The content of malonic dialdehyde increases by the end of the experiment by 8 times (NP Cu – 0.001 mg/dm3), by 42 times (NP Cu – 0.01 mg/dm3), by 3.5 times (NP Cu – 0.1 mg/dm3) and by 2 times (NP CuO– 0.001 mg/dm3, 0.01 and 0.1 mg/dm3).
KEYWORDS: copper, nanoparticles, survival, toxicity, Daniorerio.Corresponding author: A.E. Arinzhanov e-mail: firstname.lastname@example.org