Trace Elements in Medicine (Moscow)
2020, 21(1): 22-26
ORIGINAL PAPERS

THE INFLUENCE OF RHYTHMS OF THE HYDROMETEOROLOGICAL INDICES ON THE WATER-MINERAL HOMEOSTASIS IN HYPERTENSIVE DISEASE (HD)

A.K. Gulyan¹, L.A. Babayan², Ts.G. Arutyunyan², N.A. Gasparyan², A.K. Mikaelyan², S.G. Grigoryan²

¹ «Erebuni» Medical Center, Urgent Cardiology Department, Titogradyan 14, Yerevan, Republic of Armenia
² Armenian Medical Institute, Titogradyan 14, Yerevan, Republic of Armenia

DOI: 10.19112/2413-6174-2020-21-1-22-26 

ABSTRACT. 70 practically healthy subjects and 100 patients with hypertensive disease were united regimen of diet, sleep and wakefulness. Urine was collected with 4-hour portions during 3-5 days. Each specimen was analyzed for electrolytes (sodium, potassium, phosphorus, chlorine, calcium, magnesium) and trace elements (iron, copper, zinc, chromium, cadmium, vanadium). Rhythms parameters have been estimated by dispersion analysis for nonsinusoidal rhythms and by nonlinear least squares method for sinusoidal rhythms. In healthy subjects in 91% cases of 593 rhythmological investigations urinary excretion electrolytes and trace elements statistically significant rhythms were observed. Healthy subjects characterized with circadian rhythms and with definite value of mesor and amplitude within the confidence limit. Acrophases of rhythms were mostly individual. The data witness that in early stage of HD electrolytes and trace elements exeretion rhythms 22% were statistically nonsignificant. Among significant rhythms of electrolytes and trace elements excretion infradians prevail - 46%. Statistically significant rhythms of electrolytes and trace elements excretion were not revealed in most of patients in the late stage of HD. Among significant rhythms circadian prevail - 48%. The data witness that in HD the coefficient of correlation between the biorhythms and the rhythms of hydrometerological indices were statistically nonsignificant (for early stage - 37% and for late stage - 30%).

KEYWORDS: ultradian, circadian, infradian rhythms, mesor, amplitude, acrophase, hydrometerological indices.