Trace Elements in Medicine (Moscow)
2019, 20(4): 51-56
BIOELEMENTAL COMPOSITION OF ORGANS OF EXPERIMENTAL ANIMALS BY FUROSEMIDE LOADING
N.N. Chuchkova1, O.M. Kanunnikova2, M.V. Smetanina1
1 Izhevsk state medical Academy, Kommunarov str., 281, Izhevsk, 426034, Russia
2 Udmurt Federal Center, Ural branch, Russian Academy of Sciences «Scientific Center of Metallurgy Physics and Materials Science», Tatiana Baramzina str., 34, Izhevsk, 426067, Russia
ABSTRACT. The administration of furosemide to experimental animals at a dose of 30 mg / kg of body weight for 10 days leads to hypomagnesemia (the amount of magnesium is reduced by 1.65 times), hyperphosphatemia (the amount of phosphorus is increased by 54.6%), a change in the ratio of elements (calcium/magnesium in the control is ~ 2:1, with furosemide load – 3:1, calcium/phosphorus changes from 2:1 – in the control to 1:1 – in the experiment). The most significant quantitative changes are two macroelements – magnesium and calcium, and two trace elements – zinc and iron. Changes in the elemental composition are least pronounced in the blood serum. Furosemide load is accompanied by diselementosis of organs. Hypomagnesaemia is accompanied by hyper-magnesium in tissues, manifested in varying degrees, most pronounced in the organs of immunogenesis (thymus and spleen). In the myocardium the calcium content increases significantly (84.5%), which leads to a change in the ratio of Ca/Mg c 1:3 (control) to 1:6 (furosemide administration). In the tissue of the heart and kidneys with furosemide load appears not determined in the normal manganese, liver is characterized by a tenfold increase in the amount of zinc. In the spleen mass concentration phosphorus (39.5%) reduced significantly, levels calcium (52.8%) and potassium (79.5%) increased, in the thymus –amount of calcium (64.8%) and iron (26.3%) increased.
KEYWORDS: furosemide, elemental composition of organs.Corresponding author: N.N. Chuchkova E-mail: email@example.com