Trace Elements in Medicine (Moscow)
2019, 20(3): 54-61
ORIGINAL PAPERS

ELEMENTAL MARKERS IN PATIENTS WITH DIABETES TYPE 2 DIABETES MELLITUS LIVING IN THE NORTHERN REGION

T.Yа. Korchina, V.I. Korchin, K.A. Cherepanova, A.B. Bogdanovich

Khanty-Mansiysk State Medical Academy, Mira str. 40, Khanty-Mansiysk, 628011, Russia

DOI: 10.19112/2413-6174-2019-20-3-54-61 

ABSTRACT. Chemical elements are part of the body tissues, enzymes, hormones, biologically active substances. Therefore, deviations in their content caused by various factors or diseases lead to a wide range of health problems. The aim of this work was to study the provision of patients with type 2 diabetes living in the Northern region with trace elements involved in the regulation of carbohydrate metabolism and antioxidant protection of the body, namely calcium (Ca), magnesium (Mg), chromium (Cr), zinc (Zn) and selenium (Se). 132 adult residents of the city were examined. Khanty-Mansiysk: 78 (59,1%) – patients with type 2 diabetes mellitus (DM) and 54(40,9%) – relatively healthy volunteers in the age range of 40-65 years. The concentration of trace elements in the hair was determined by inductively coupled plasma mass spectrometry. In patients with diabetes insufficiency of trace elements contributing to the processing of glucose into lipids was established: Ca in 34,7% and Mg in more than a quarter. Significantly lower concentrations of trace elements involved in the regulation of glucose metabolism – Cr (p<0,001) and Zn (p=0,027) and included in the antioxidant enzymes were established in the hair: Zn and Se (p<0,001) in patients with type 2 DM compared with similar indicators in patients without DM. In order to optimize the treatment and improve the quality of life of patients with type 2 DM, it is necessary, in addition to diet therapy and drug treatment, to correct the micronutrient status with the help of special monopreparations containing appropriate Bioelements and enriched food products after elemental analysis of hair.

KEYWORDS: patients with type 2 diabetes mellitus, carbohydrate metabolism, oxidative stress, trace ele-ments-antioxidants.