Trace Elements in Medicine (Moscow)
2019, 20(1): 43-51
ORIGINAL PAPERS

THE REGULATORY CRITERIA FOR METAL-LIGAND HOMEOSTASIS IN EPIDERMAL CELLS

V.I. Petukhov¹, Е.V. Dmitriev², L.Kh. Baumane³, A.V. Skalny⁴, Yu.N. Lobanova⁴, A.R. Grabeklis⁴

¹Vladimir State University, Gorky str., 87, Vladimir, 600000, Russia
²Marchuk Institute of Numerical Mathematicsof the Russian Academy of Sciences, Gubkina str., 8,119333,Moscow, Russia
³Latvian Institute of Organic Synthesis, Aizkraukles str., 21, Riga LV 1006, Latvia
⁴ Peoples' Friendship University of Russia, Miklukho-Maklaya str. 6, Moscow, 117198; Yaroslavl State University, Sovetskaya str., 14, Yaroslavl, 150000, Russia

DOI: 10.19112/2413-6174-2019-20-1-43-51 

ABSTRACT.The work is dedicated to the problem of the norm in the quantitative evaluation of metal content in the epidermal cells (hair) obtained by the method of spectrometry. Authors have analyzed the hair samples for Zn, Cu, and Fe content, which were obtained from 10000 healthy subjects (5000 males and 5000 females aged 20 to 45). The definition of the norm, in the authors’ opinion, is closely related to the basic positions of the theory of self-organized criticality (SC). The observed shifts in the homeostasis of essential metals are local and therefore cannot serve as a cri-terion of sufficient (or insufficient) metal content throughout the body.

KEYWORDS:metal-ligand homeostasis, redox status, epidermis, self-organized criticality, oxidative/ nitrosative stress.