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Trace Elements in Medicine
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MACRO AND TRACE ELEMENTS IN SERUM OF PATIENTS WITH ISCHEMIC STROKE AT DIFFERENT LEVEL OF THE VEGF NEUROSPECIFIC PROTEIN

Trace Elements in Medicine (Moscow)
2018, 19(4): 59-62
SHORT COMMUNICATIONS

MACRO AND TRACE ELEMENTS IN SERUM OF PATIENTS WITH ISCHEMIC STROKE AT DIFFERENT LEVEL OF THE VEGF NEUROSPECIFIC PROTEIN

L.L. Klimenko1, A.I. Deev1, I.S. Baskakov1, M.N. Budanova1, A.N. Mazilina2, M.S. Savostina2, A.A. Turna3, A.V. Kuznetsova4

1 Semenov Institute of Chemical Physics at Russian Academy of Sciences, Kosygina st., 4 bld 1, Moscow, 119991, Russia
2 Clinical Hospital № 123 at Federal Medical and Biological Agency of Russia, Krasnogorskoe shosse, 15, Odintsovo, Moscow region, 143000, Russia
3 Institute of Advanced Studies at Federal Medical and Biological Agency of Russia, Volokolamskoe shosse, 91, Moscow, 125371, Russia
4 Institute for Biochemical Physics at Russian Academy of Sciences, Kosygina st., 4, Moscow, 119334, Russia

DOI: 10.19112/2413-6174-2018-19-4-59-62 

ABSTRACT. Due to the high relevance of the problem of searching for early biomarkers of neurotrophic dysfunctions, the levels of the neurospecific protein VEGF and some of macro- and trace elements in the blood serum during ischemic brain pathology were studied in a clinical setting at the neurological department of Clinical Hospital No. 123 of the FMBA of Russia. The study included male patients (n = 51) diagnosed with ischemic stroke, mean age 65±0.3 years. The comparison group was represented by healthy male volunteers (n = 39), average age 62±0.6 years. Concentration of VEGF was determined by enzyme immunoassay, concentration of elements Mg, Mn, Cu, Se, Zn was determined by mass spectrometry with inductively coupled argon plasma (ICP-MS). It was found that in patients with cerebral pathology the level of VEGF was 4.7-fold higher than in the control group, the serum copper content exceeded the corresponding value of the control group 1.2-fold, the manganese content – 1.8-fold, the selenium and zinc content – 1.3-fold. The presence of significant correlations between the level of VEGF and all studied essential elements was also found. For copper, manganese, magnesium and selenium, the correlation was positive (R = 0.4–0.8; p <0.05), and for zinc it was negative (R = 0.8; p < 0.05). The results indicate the probable presence of multilevel mechanisms of ischemic stroke, presented at the molecular and biochemical levels, as well as the possibility of developing a strategy to optimize the reparative processes of ischemic nervous tissue by modulating metal ligand homeostasis.

KEYWORDS: ischemic stroke, VEGF, serum, magnesium, manganese, copper, selenium, zinc.

Corresponding author: L.L. Klimenko E-mail: klimenkoll@mail.ru