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Trace Elements in Medicine
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THE INFLUENCE OF GLUTHATION-CONTAINING DINITROSYL IRON COMPLEXES ON SOME PARAMATERS OF RATS’ BLOOD

Trace Elements in Medicine (Moscow)
2018, 19(4): 52-58
ORIGINAL PAPERS

THE INFLUENCE OF GLUTHATION-CONTAINING DINITROSYL IRON COMPLEXES ON SOME PARAMATERS OF RATS’ BLOOD

A.K. Martusevich1,2, A.G. Soloveva1, L.K. Kovaleva2, A.A. Martusevich3

1Privolzhsky Research Medical University, Verhnevolzhskaya emb., 18/1, Nizhny Novgorod, 603005, Russia
2 Kirov State Medical University, Karl Marx str., 112, Kirov, 610006, Russia
3 National Research Nizhny Novgorod State University named after N.I. Lobachevsky, Gagarin av., 23, Nizhny Novgorod, 603950, Russia

DOI: 10.19112/2413-6174-2018-19-4-52-58 

ABSTRACT. The aim of this work was estimation of dinitrosyl iron complexes (DNIC) influence on energy metabolism and aldehyde dehydrogenase activity of rats’ erythrocytes. Our experiment was carried out on 60 male Wistar rats, divided into 6 equal groups. First group was intact (without any manipulations). Rats of other groups got a course of intraperitoneal administration of 1 ml. of saline during 10 days. For rats of third to sixth groups saline additionally contained the dinitrosyl iron complexes with glutathione ligands (concentration - 0,15; 0,30; 0,45 and 0,60 мМ, respectively). It is stated thet intraperitoneal infusions of DNIC stimulates energy metabolism of the blood in healthy rats. It includes in stimulation of direct reaction of lactate dehydrogenase and inhibition of reverse one. We also fixed decreasing of lactate in erythrocytes. This tendency was maximal at 0,3 and 0,45 mM of DNIC use. Similar changes were registered with aldehyde dehydrogenase.

KEYWORDS: nitric oxide, dinitrosyl iron complexes, energy metabolism, aldehyde dehydrogenase.

Corresponding author: A.K. Martusevich E-mail: cryst-mart@yandex.ru