Trace Elements in Medicine (Moscow)
2017, 18(2): 37–42
ORIGINAL PAPER

TO THE QUESTION OF PATHOGENETIC SIGNIFICANCE OF HEAVY METALS DISGOMEOSTASIS IN PATIENTS WITH PROSTATE ONCOGENIC DISEASES

L.M. Shafran1, E.G. Pykhteeva1, D.V. Bolshoy1, A.J. Kwasniewsky2, G.A. Samunzhi3

1 Ukrainian Scientific and Research Institute of Transport Medicine, Kanatnaya str. 92, Odessa 65039, Ukraine
2 Military Medical Clinical Center of the Southern region, Pirogovskaya str. 2/2, Odessa 65044, Ukraine
3 Odessa National Medical University, Valikhovskiy lane, 2, Odessa 65026, Ukraine

DOI: 10.19112/2413-6174-2017-18-2-37-42 

ABSTRACT. A comprehensive survey of 212 patients and 37 healthy male people was conducted to study the role of heavy metals in the pathogenesis of benign prostatic hypertrophy (BPH), and prostate cancer (PCa). These diseases are common among older age groups of the male population and characterized by the high mortality level. The study has identified changes in trace-element composition and showed their role in the disease pathogenesis. We identified informative biomarkers for diagnostic and prognostic evaluation and managed methods of metals disgomeostasis correction. Also the article sheds light on possibilities for preventing complications. Along with the practical significance in the urological clinic, the made work is of scientific interest to the medical metallomics.

KEYWORDS: heavy metals, prostate cancer, biomarkers